糖尿病患者心脏自主神经病变相关因素研究

出境目的探讨糖尿病心脏自主神经病变（CAN）的相关危险因素。方法712例2型糖尿病患者根据心血管自主神经功能试验结果分为病变组与对照组,观察两组患者病程、职业、体质指数（BMI）、血糖、血脂、糖化血红蛋白（HbA1C）、尿微量白蛋白排泄率（UAER）等指标并进行比较分析。结果病变组病程、空腹血糖（FBG）、甘油三酯（TG）、极低密度脂蛋白胆固醇（VLDL-C）、载脂蛋白B（APOB）、UAER高于对照组（P〈0.05）,高密度脂蛋白胆固醇（HDL-C）低于对照组（P〈0.05）;多元逐步回归分析提示,CAN与糖尿病病程、HbA1C、VLDL-C、TG正相关,与HDL-C负相关。结论CAN的发生与糖尿病病程、血糖、血脂有关。

Study on Correlated Risk Factors for Cardiovascular Autonomic Neuropathy in Diabetic Patients

Objective To investigate the relevant risk factors for cardiovascular autonomic neuropathy （CAN） in diabetic patients. Methods 712 cases of diabetic patients were divided into two groups according to their cardiovascular autonomic function test： one group with CAN （n=160）, and the other without CAN （n=552）. Duration of diabetes, profession, body mass index （BMI）, blood glucose, lipid profile, glycosylated hemoglobin （HbA1c） and urinary albumin excretion rate （UAER） were measured. Results Duration of diabetes, the levels of fasting plasm glucose （FBG）, triglyceride （TG）, VLDL-C, APOB, UAER were significantly higher in CAN group than in non-CAN group （P〈0.05）, HDL-C in CAN patients were lower than those in non-CAN patients （P〈0.05）. Logistic regression analysis showed that CAN was positively correlated with duration of diabetes, HbA1C, TG and VLDL-C, while negatively correlated with HDL-C. Conclusion CAN is related with duration of diabetes, blood glucose and serum lipid.