苯妥英治疗急性脑梗塞的疗效及其对脑循环动力学的影响

用随机对照方法静脉滴注苯妥英治疗急性脑梗塞２５例，观察神经功能缺失改变及首剂苯妥英静滴前后的脑循环动力学改变，结果显示，用苯妥英治疗后，脑梗塞患者神经功能缺失明显改善，总有效率达９２％，显效率达６８％，与未用苯妥英组比较差异显著（Ｐ＜０．０５）；治疗期间未见明显毒副作用。静滴苯妥英２５０ｍｇ后，颈动脉系统血流速度及血流量增加，外周小血管阻力下降，但无统计学差异。而静滴苯妥英５００ｍｇ，则可显著增加颈动脉系统血流速度及血流量（ｐ＜０．０１），降低外周小血管阻力（Ｐ＜０．０１）。提示苯妥英对缺血性脑组织有一定保护作用。

Clinical Efficacy of Phenytoin and Its Effect on Cerebral Hemodynamics in Patients with Acute Cerebral Infarction

patients with acute cerebral infarction were recieved phenytoin in fusion intra venously, its clinical efficacy and its effect on cerebral hemodynamic changes were estimated, The results showed that the neurologic deficits of patients were improved,its rate of improvement(92%)was better than 27 control patients (P<0. 05 ).The changes of cerebral hemodynamic parameterswere significantly improved in patients received 500 mg phenytoin, but not in patients received 250mg phenytoin. The results suggested that there is a certain protective effect of phenytoin on ischemic brain tissue in patients with acute cerebral infarction.