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| 髓源性抑制细胞——血液肿瘤的免疫治疗靶点 | |
| 引用本文： | 刘静静,金财宝,许秀文,朱晓健,孟力. 髓源性抑制细胞——血液肿瘤的免疫治疗靶点[J]. 国际肿瘤学杂志, 2017, 44(4). DOI: 10.3760/cma.j.issn.1673-422X.2017.04.020 |
| 作者姓名： | 刘静静 金财宝 许秀文 朱晓健 孟力 |
| 作者单位： | 华中科技大学同济医院血液内科,武汉,430030 |
| 基金项目： | 国家自然科学基金(81272422)National Natural Science Foundation of China |
| 摘 要： | 近年来,髓源性抑制细胞(MDSC)成为实体瘤和血液肿瘤的研究热点.在肿瘤中,MDSC不仅通过抑制T细胞增殖、破坏自然杀伤细胞功能和上调调节性T细胞水平发挥免疫抑制作用,还可直接发挥促进肿瘤血管生成和肿瘤转移的非免疫方面的作用.MDSC阻碍了抗肿瘤治疗,尤其影响了免疫治疗的疗效,与临床预后不良相关,可作为肿瘤预后的判断指标,为免疫治疗提供了新靶点. |
| 关 键 词： | 免疫抑制剂 治疗 髓源性抑制细胞 |
Myeloid-derived suppressor cells-immunotherapy targets in hematological malignancies |
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| Liu Jingjing,Jin Caibao,Xu Xiuwen,Zhu Xiaojian,Meng Li. Myeloid-derived suppressor cells-immunotherapy targets in hematological malignancies[J]. Journal of International Oncology, 2017, 44(4). DOI: 10.3760/cma.j.issn.1673-422X.2017.04.020 | |
| Authors: | Liu Jingjing Jin Caibao Xu Xiuwen Zhu Xiaojian Meng Li |
| Abstract: | In recent years, the research hot in the field of solid tumor and blood tumor focuses on the myeloid-derived suppressor cells (MDSCs).In tumors, MDSCs not only exert immunosuppression by inhibiting T cell proliferation, destroying the functions of natural killer cells and recruiting regulatory T cells, but also play non-immunosuppression roles in the promotion of angiogenesis and tumor metastasis.All of these hinder the anti-tumor therapy, and particularly affect the curative effect, which are related with a poor clinical prognosis.MDSCs can be used as prognostic markers, which provide new targets for immunotherapy. |
| Keywords: | Immunosuppressive agents Therapy Myeloid-derived suppressor cells |
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