槐花散联合仙方活命饮治疗溃疡性结肠炎临床研究

目的 评价槐花散联合仙方活命饮治疗溃疡性结肠炎的临床疗效.方法 将80例热毒炽盛型溃疡性结肠炎按照随机数字表法分为2组,每组40例.对照组口服美沙拉嗪肠溶片,观察组给予槐花散联合仙方活命饮.2组均治疗8周.采用ELISA法检测血清TNF-α、IL-8;采用Mayo疾病活动指数评价疾病的严重程度,评价临床疗效.结果 治疗后,观察组TNF-α(66.11±3.72)ng/L比(92.61±4.32)ng/L,t=29.398]、IL-8(53.11±2.72)ng/L比(69.31±1.32)ng/L,t=33.888]均低于对照组(P<0.01).观察组结肠镜像积分(0.74±0.18)分比(1.25±0.49)分,t=6.179]、Mayo指数评分(2.07±0.57)分比(3.30±0.93)分,t=7.132]均低于对照组(P<0.01).观察组总有效率为92.5%(37/40)、对照组为85.0%(34/40),2组比较差异无统计学意义(χ2=1.127,P=0.288).观察组复发率为5.4%(2/37)、对照组为26.5%(9/34),2组比较差异无统计学意义(χ2=6.005,P=0.013).结论 槐花散联合仙方活命饮可降低热毒炽盛型溃疡性结肠炎患者炎症因子水平,与口服美沙拉嗪肠溶片疗效相当.

Clinical study on the clinical effect of Sophora powder combined with Xianfang-Huoming decoction for ulcerative colitis

Objective To explore the clinical effect of Sophora powder combined with Xianfang-Huoming decoction for ulcerative colitis.Methods A total of 80 UC patients with TCM syndrome of excessive noxious heat were randomly divided into 2 groups (40 patients each group). The Western medicine group(control group) were treated with Mesalazin Enteric-coated tablets, and the Traditional Chinese medicine(observation group) group were treated with Sophora powder combined with Xianfang-Huoming decoction. The tumor necrosis factor-α(TNF-α)and Interleukin-8(IL-8) were detected. The Mayo index scores were conducted, and the curative effect and the recurrence rate were observed.ResultsAfter treatment, the level of TNF-α (66.11 ± 3.72 ng/Lvs. 92.61 ± 4.32 ng/L,t=29.398,P﹤0.01), IL-8 (53.11 ± 2.72 ng/L vs. 69.31 ± 1.32 ng/L,t=33.888,P﹤0.01)in the observation groupwere significantly lower than those in the control group. The Mayo index score (2.07 ± 0.57 vs. 3.30 ± 0.93, t=7.132,P﹤0.01) in the observation group was significantly lower than that in the control group. The total effective rate (92.5% vs. 85.0%,χ2=1.127, P=0.288) in the observation group was not significantly different from that in the control group. The recurrence rate (5.4% vs. 26.5%,χ2=6.005,P=0.013) in the observation group was significantly lower than that in the control group.Conclusions The Sophora powder combined withXianfang-Huoming decoction can treat the UC patients with TCM syndrome of excessive noxious hest, and the its recurrence rate is low.