|
|||||
|
|
| Musashi2及相关信号通路在恶性肿瘤发生发展中的作用及机制 | |
| 引用本文： | 李佳润,葛乔枫,郭庚,王小刚. Musashi2及相关信号通路在恶性肿瘤发生发展中的作用及机制[J]. 国际肿瘤学杂志, 2017, 44(3). DOI: 10.3760/cma.j.issn.1673-422X.2017.03.008 |
| 作者姓名： | 李佳润 葛乔枫 郭庚 王小刚 |
| 作者单位： | 1. 100034,北京大学第一医院老年病科;2. 山西医科大学第二医院骨科;3. 山西医科大学第一医院神经外科 |
| 基金项目： | 国家自然科学基金，中国博士后科学基金，北京市博士后工作经费资助项目，山西省自然科学基金，山西省高等学校创新人才支持计划，山西省卫生厅科研课题(201301066)National Natural Science Foundation of China，China Postdoctoral Science Foundation，Project Supported by Beijing Postdoctoral Research Foundation，Natural Science Foundation of Shanxi Province of China，Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi Province，Scientific Research Subject of Shanxi Provincial Health Department |
| 摘 要： | 在哺乳动物中,RNA结合蛋白Musashi(Msi)1和Msi2共同组成了Msi家族.其中,Msi2主要分布于神经、造血、胃肠、胰腺和上皮组织干细胞内,其在维持干细胞增殖和分化的平衡、调控干细胞的生长发育中起关键作用.该蛋白的表达改变会通过多种信号通路诱导恶性肿瘤的发生发展.Msi2的深入研究将为相关肿瘤提供预测标志及治疗靶点. |
| 关 键 词： | 肿瘤 机制 Musashi2 |
Effect and mechanism of Musashi2 and related signal pathways in genesis and progression of malignant tumor |
|
| Li Jiarun,Ge Qiaofeng,Guo Geng,Wang Xiaogang. Effect and mechanism of Musashi2 and related signal pathways in genesis and progression of malignant tumor[J]. Journal of International Oncology, 2017, 44(3). DOI: 10.3760/cma.j.issn.1673-422X.2017.03.008 | |
| Authors: | Li Jiarun Ge Qiaofeng Guo Geng Wang Xiaogang |
| Abstract: | In mammals,there are two RNA-binding proteins,Musashi (Msi)1 and Msi2,constituting the Msi family.Msi2 is mainly distributed among neural,hematopoietic,gastrointestinal,pancreatic and epithelial stein cells.It is of great importance to maintain the balance between proliferation and differentiation of stem cells and regulate their growth and development.The changed expression of this protein will induce genesis and progression of malignant tumor through many kinds of signal pathways.Thus,Msi2 is trusted to provide a predictive mark and a therapeutic target for related tumors. |
| Keywords: | Neoplasms Mechanism Musashi2 |
| 本文献已被 万方数据 等数据库收录！ | |