肺损伤性毒剂的实验研究进展

肺损伤性毒剂,也称肺刺激剂和窒息性毒剂,作用靶器官主要是肺,可引起潜在持久的呼吸抑制,并可迅速发展为急性肺损伤(ALI)、肺水肿,严重者将导致死亡.近年来,随着对其作用机制研究的深入,开展了不少针对性的实验研究,并取得了一定的进展.本文从肺损伤性毒剂研究概况、致病机制、生物标志物等3个方面综述了近年来肺损伤性毒剂实验研究的相关进展,为推动中毒性ALI的预防、诊断和临床治疗提供参考借鉴.

Experimental study on lung-damaging agents:research advances

Lung is the main target of lung-damaging agents(or choking agents,lung irritants)which can result in potential permanent respiratory depression,the rapid development of acute lung injury(ALI)and pulmonary edema,even death in severe cas-es. Recently,with the research progress in the pathogenesis of lung-damaging agents,numerous corresponding experimental studies were carried out and some progress were made. This paper summarizes the progress in the study of lung-damaging agents on the re-search situation,pathogenic mechanism and biomarker,to provide reference for the promotion of ALI prevention,medical antagonis-tic measures and clinical treatment.