p170和p53在乳腺癌组织的表达及临床意义

目的：探讨乳腺癌组织中p170和053的表达及两者之间的关系和临床意义。方法：采用S—P免疫组化法检测96例乳腺癌石蜡标本中p170和053蛋白的表达，分析其与临床病理因素的关系及两者的相关性。结果：96例乳腺癌组织中p170阳性表达率为65．25％（54／96），其表达与患者年龄、肿瘤大小、病理分级、ER和PR表达及淋巴结转移无关。053阳性表达率为41．67％（40／96），其表达与病理分级呈正相关、与患者年龄、病理分型、ER和PR表达及淋巴结转移无明显相关，p170与p53的表达成正相关。结论：p170与p53的表达呈正相关，他们是重要的病理指标，对肿瘤化疗药物的选择有指导意义。

Expression of p170 and p53 in breast cancer and clinical significance

Objective：To investigate the expression of p170 and p53 in breast cancer ,and to explore their relationship and clinical significance. Methods： Immunostaining （ S - P ） was performed for p170 and p53 on 96 specimens of breast cancer. Results： The rate of positive expression of p170 was 65.25% （54/96） , which had no corre lation with age, tumor size ,axillas lymph nodes metastasis , pathological grades, pathological classification and expression of ER,PR . The positive expression rate of p53 was 41.67% （ 40/96 ）, which had correlation with the historical grades, had no correlation with age , tumor size , axillas lymph nodes metastasis , pathological classification and expression of ER,PR. The expression rate of p170 had positive correlation with p53. Conclusion： The expression rate of p170 had a positive correlation with p53. They were important pathological signs of the breast cancer. These markers play an important role in choosing clinical chemotherapy drugs.