仙灵骨葆胶囊致肝功能异常2例

2名患者服用仙灵骨葆胶囊治疗骨质疏松症引致肝功能异常。第1例为65岁女性高血压伴脑供血不足患者,长期服用降压0号和银杏叶片。2004年2月24日开始加用仙灵骨葆胶囊1.5g,2次/d,6个月后体检发现其ALT和AST分别为85U/L和93U/L,停用仙灵骨葆胶囊,继续服用降压0号和银杏叶片。追踪随访,停药约20个月后,患者的ALT和AST分别下降为17U/L和28U/L。第2例为68岁女性萎缩性胃炎患者,长期服用西沙必利,2004年1月患者开始服用仙灵骨葆胶囊1.5g,2次/d。2个月后,实验检查显示:ALT158U/L,AST123U/L。停用仙灵骨葆胶囊,仍服西沙必利,并加服葡醛内酯200mg,3次/d,连续服用15d。约6个月后,患者的ALT为35U/L,AST为23U/L。

Liver dysfunction resulting from Xianlinggubao capsules in 2 CASES

Two patients developed liver dysfunction after treatment with Xianlinggubao capsules for osteoporosis. The first patient, a 65-year-old woman with hypertension and cerebral insufficiency, was treated with Jiangyalinghao and ginkgo biloba leaf tablets. And then her regimen was added to Xianlinggubao capsules 1.5g twice daily. Six months later, laboratory inves- tigations revealed ALT and AST levels of 85 U/L and 93 U/L, respectively. Xianlinggubao capsules were stopped, and Jiangyalinghao and ginkgo biloba leaf tablets were continued. After 20 months of cessation of Xianlinggubao capsules, her ALT and AST levels decreased to 17 U/L and 28 U/L, respectively. The second patient, a 68-year-old woman with atrophic gastritis, was receiving a long-term therapy with cisapride. And then her regimen was added to Xianlinggubao capsules1.5g twice daily. Two months later, laboratory tests showed following values: ALT 158 U/L and AST 123 U/L. Xianlinggubao capsules were discontinued, and cisapride was continued. In addition, the patient was administered with glucurolactone 200 mg thrice daily for 15 days. Approximately 6 months later, her ALT was 35 U/L and AST was 23 U/L.