我院120例药品不良反应报告分析

目的：分析我院药品不良反应（ADR）发生的特点与一般规律，促进临床合理用药。方法：采用回顾性方法，对我院2007年1～6月上报的120份ADR报告，按患者年龄、性别、给药途径、引起ADR的药品种类、涉及器官或系统以及临床表现等进行统计、分析。结果：静脉给药较其他给药途径更易发生ADR（占68.3%）；抗感染药物引发ADR的比例最高（占46.7%），其次为神经系统与心血管系统药物；氟喹诺酮类是引发ADR的主要抗感染药（19例，占33.9%），其中又以左氧氟沙星为首。ADR的临床表现以皮疹、瘙痒等皮肤及附件损害为主，其次为消化系统以及循环系统损害。结论：应强化ADR监测意识，完善相关报告分析制度，确保临床安全、有效、合理用药。

ADR Reports:Analysis of 120 Cases in Our Hospital

OBJECTIVE:To analyze the characteristics and regularity of the adverse drug reaction(ADR) occurred in our hospital so as to promote rational drug use.METHODS:By a retrospective study,a total of 120 ADR case reports collected from our hospital from Jan.to June in 2007 were subjected to a statistical analysis in respect of patients' age and sex,route of administration,drug categories inducing ADRs,the organs or system involved and the clinical manifestations etc.RESULTS:Of the total 120 ADR cases,68.3% were induced by intravenous administration,and 46.7% were induced by anti-infective drugs,followed by drugs used for nervous system and cardiovascular disease.Quinolones were the major anti-infective drugs,which caused ADR in 19 cases(33.9%),of all the quinolones used,levofloxacin took the lead.The ADRs manifested dominantly by skin rash and pruritus followed by lesions of digestive system and circulatory system.CONCLUSION:ADR monitoring should be strengthened and the related ADR reporting and analyzing system should be evolved to ensure clinical safe,effective and rational use of drugs.