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A comparative study of once-a-day morning and once-a-day bedtime administration of 40 mg famotidine in treating duodenal ulcers |
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| Authors: | Mitsuo Okada M.D. Masahide Arita Mitsuo Iida Tsuneyoshi Yao Toshihiro Sakurai Kiyomi Hoshiko Kazuhiro Maeda Yasuhiro Okada Kiyoto Sakamoto |
| Affiliation: | 1. First Department of Internal Medicine, School of Medicine, Fukuoka University, 45-1, 7-chome, Jonan-ku, 814-01, Fukuoka City, Japan 2. Department of Internal Medicine and Gastroenterology, Fukuoka University Chikushi Hospital, Chikushino, Japan 3. Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan 4. Gastroenterology Department, Fukuoka Red Cross Hospital, Fukuoka, Japan 5. Department of Internal Medicine, Kyushu Central Hospital, Fukuoka, Japan |
| Abstract: | A randomized controlled study comparing once-a-day morning and once-a-day bedtime administration of 40 mg famotidine in treating duodenal ulcers was carried out in 99 Japanese patients. Endoscopic examinations were performed at the baseline and repeated at 3-week intervals until healing was confirmed. Eighty-two patients fulfilled the evaluation criteria (38 in the morning group and 44 in the bedtime group). In 13 of these patients the antisecretory effects of these regimens were also assessed by 24 h intragastric pH monitoring. The healing rates were 66% after 3 weeks and 95% after 6 weeks in the morning group, and 57% after 3 weeks and 80% after 6 weeks in the bedtime group. The differences were insignificant between the two groups, but there was a higher healing rate tendency after 6 weeks in the morning group (0.05 |
| Keywords: | duodenal ulcer famotidine gastric acid secretion optimum time for treatment |
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