库欣病经蝶手术复发的影响因素

目的探讨可能影响库欣病经蝶手术后复发的因素。方法回顾性分析了1992~2002年在我科接受经蝶手术治疗的182例库欣病患者的临床资料。结果接受经蝶手术后库欣病患者的复发率与术前MRI发现肿瘤与否(P=0·001)、肿瘤切除方式(P=0·001)、肿瘤病理类型(P=0·04)及术后激素下降水平(P=0·02)有关,而与肿瘤大小无关(P=0·43)。结论术前MRI发现肿瘤与否、肿瘤切除方式、肿瘤病理类型及术后激素下降水平是库欣病手术复发的影响因素。

Factors influencing the recurrence of Cushing's disease treated by transsphenoidal surgery

Objective To explore factors influencing the recurrence of patients with Cushing's disease after transsphenoidal surgery. Methods We retrospectively analyzed the clinical data of 182 patients treated by transsphenoidal surgery with Cushing's disease in our department in PUMC Hospital from 1992 to 2002. Results The recurrence rates were significantly different when patients had different radiological findings(P=0.001), operative methods(P=0.001), histological findings(P=0.04), and postoperative cortisol levels (P=0.02); however, such difference was not found in term of tumor size (P=0.43). Conclusion Radiological findings, operative methods, histological findings,and postoperative cortisol estimates may be the factors influencing the recurrence of patients treated by transsphenoidal surgery.