Myelography with a dimeric (iodixanol) and a monomeric (iohexol) contrast medium: a clinical multicentre comparative study |
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Authors: | I O Skalpe J F Bonneville P Grane C Gyldenstedt B Otto D T Kristoffersen M G Svaland |
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Institution: | Nevroradiologisk Seksjon, Rikshospitalet, Pilestredet 32, N-0027 Oslo, Norway, NO Service de Radiologie B, H?pital Jean Minjoz, Boulevard A. Fleming, F-25 030 Besancon Cedex, France, FR Neuroradiologiska avdelningen, Karolinska Sjukhuset, P. O. Box 60500, S-171 76 Stockholm, Sweden, SE Neuroradiologisk Afdeling P, N?rrebrogade 44, DK-8000 Aarhus C, Denmark, DK Service de Radiologie, H?pital de la Citadelle, Boulevard du Xlle de Ligne, B-4000 Liege, Belgium, BE Nycomed Imaging AS, P. O. Box 4220 Torshov, N-0401 Oslo, Norway, NO
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Abstract: | The purpose of this study was to evaluate and compare the radiographic efficacy and safety of iodixanol (Visipaque; 270 and
320 mg I/ml) and iohexol (Omnipaque; 300 mg I/ml) in myelography. The study was randomized, double-blind and comparative including
398 patients from five European university clinics. The radiographic visualisation was evaluated as poor, good or excellent.
Adverse events were recorded by interviewing the patients after the myelography, and each patient was given a questionnaire
to be returned after 1 week. In cervical myelography with cervical puncture more films with excellent quality was obtained
after iodixanol 320 mgI/ml compared with iohexol 300 mgI/ml (p = 0.009). Also in lumbar myelography iodixanol 320 mgI/ml compared favourably with iohexol 300 mgI/ml (p = 0.006). The most frequent adverse event was headache, which occurred in 5–35 % of patients during the first 24 h and in
19–61 % within the first 7 days, depending on the centre. There was no difference in frequency and severity of the adverse
effects between the contrast media.
Received 13 March 1997; Revision received 29 December 1997; Accepted 5 January 1997 |
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Keywords: | : Myelography Iodixanol Dimeric contrast medium Safety Efficacy |
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