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Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers |
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| Authors: | Jessica Dennis Parviz Ghadirian Julian Little Jan Lubinski Jacek Gronwald Charmaine Kim-Sing William Foulkes Pal Moller Henry T. Lynch Susan L. Neuhausen Susan Domchek Susan Armel Claudine Isaacs Nadine Tung Kevin Sweet Peter Ainsworth Ping Sun Daniel Krewski Steven Narod the Hereditary Breast Cancer Clinical Study Group |
| Affiliation: | a Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Canada;b McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada;c Centre Hospitalier de l’Universitaire Montréal, CHUM Hôtel Dieu, Montreal, Canada;d Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland;e BC Cancer Agency, Vancouver, BC, Canada;f Departments of Medical Genetics and Oncology, McGill University, Canada;g Section of Cancer Genetics, Department of Medical Genetics, The National Hospital, Oslo, Norway;h Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, NE, USA;i Department of Epidemiology, University of California at Irvine, Irvine, CA, USA;j Abramson Cancer Center, University of Pennsylvania School of Medicine, USA;k Department of Obstetrics and Gynecology, University Health Network, Toronto, Ontario, Canada;l Lombardi Cancer Center, Georgetown University Medical Center Georgetown, Washington, DC, USA;m Beth Israel Deaconess Hospital, Boston, MA, Ohio, USA;n Division of Medical Genetics, Ohio State Medical Center, Columbus OH, USA;o London Regional Cancer Program, London, Ontario, Canada;p Women’s College Research Institute, Women’s College Hospital and the University of Toronto, Canada |
| Abstract: | Alcohol consumption increases the risk of breast cancer among women in the general population, but its effect on women who carry a BRCA gene mutation is unclear. We conducted a case-control study of 1925 matched pairs of predominantly premenopausal women who carry a BRCA1 or a BRCA2 mutation. Information on current alcohol consumption was obtained from a questionnaire administered during the course of genetic counselling or at the time of enrolment. A modest inverse association between breast cancer and reported current alcohol consumption was observed among women with a BRCA1 mutation (OR = 0.82, 95% CI 0.70–0.96), but not among women with a BRCA2 mutation (OR = 1.00; 95% CI 0.71–1.41). Compared to non-drinkers, exclusive consumption of wine was associated with a significant reduction in the risk of breast cancer among BRCA1 carriers (p-trend = 0.01). Alcohol consumption does not appear to increase breast cancer risk in women carrying a BRCA gene mutation. |
| Keywords: | BRCA1 BRCA2 Alcohol Breast cancer Case-control Wine |
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