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Neurotoxicodynamics of the Interaction between Ciprofloxacin and Foscarnet in Mice |
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| Authors: | Hirotami Matsuo Miwako Ryu Aya Nagata Takahiro Uchida Jun-Ichi Kawakami Koujirou Yamamoto Tatsuji Iga Yasufumi Sawada |
| Affiliation: | Faculty of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582,1. and Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-8655,2. Japan |
| Abstract: | The potential for convulsions induced by the coadministration of ciprofloxacin (CPFX) and foscarnet (PFA) may be due not to a change in the distribution of CPFX to the brain but to a potential CPFX-induced inhibition of γ-aminobutyric acid (GABA)-GABAA receptor binding in the presence of PFA. |
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