99Tcm-DTPA肾动态显像与血清胱抑素C测定法在肾小球功能评价中的对比研究

目的 比较99Tcm-二亚乙基三胺五乙酸(99Tcm-DTPA)肾动态显像和血清胱抑素C测定两种方法在评价肾小球滤过功能中的差别.方法 随机抽取100例患者,其中高血压病患者38例、肾脏病患者35例、动脉硬化性闭塞症患者10例、糖尿病患者9例、其他疾病患者8例.分别通过99Tcm-DTPA肾动态显像法和血清胱抑素C测定法评估肾小球滤过功能.结果 两种方法所测得的肾小球滤过率(GFR)差异无统计学意义(t=1.591,P＞0.05),且呈线性相关(r=0.809,P＜0.01);放射性核素肾动态显像法在测定GFR的同时,还可以获得分肾功能,观察双肾血流灌注和排泄状况.结论 用99Tcm-DTPA肾动态显像与血清胱抑素C测定两种方法评估GFR,结果无显著差异,且相关性很好.前者可以获得分肾功能,对肾功能状态的评估更为全面;而后者测定方法简便、省时,且价廉,更适合于对临床患者肾功能的筛查.

Comparative study between 99Tcm-MDP renal dynamic imaging and measurement of serum cystatin C in evaluation of glomerular function

Objective To compare the difference between 99Tcm-diethylenetriaminepentaacetic acid (99Tcm-DTPA) renal dynamic imaging and measurement of serum cystatin C in evaluation of glomerular filtration rate (GFR). Methods One hundred patients were selected at random, 38 cases with hy-pertension, 35with nephrosis, 10 with arteriosclerosis obliterans, 9 with diabetes and 8 with other diseases. Evaluation of patients'GFR was made separately by 99Tcm-DTPA renal dynamic imaging and measurement of serum cystatin C. Results No significant difference of GFR was found between the two methods (t=1.591, P＞0.05 ),and linear correlation was showed as well (r=0.809, P＜0.01 ). The imaging also revealed the function of individaul kidney, renal blood perfusion and excretory function besides GFR. Conclusions Results of GFR from the two methods revealed no significant difference and they were highly correlated. 99Tcm-DTPA renal dynamic imaging could reveal the individual renal function and provide a more comprehensive evaluation of renal function while the measurement of serum cystatin C was simple and convenient, timesaving, economic, and more suit-able for screening patients'renal function clinically.