胰岛素样生长因子ⅡmRNA结合蛋白-3在结肠癌中的表达及临床意义

目的 探讨胰岛素样生长因子ⅡmRNA结合蛋白-3(IMP3)在结肠癌中的表达及其意义.方法 应用组织芯片免疫组织化学方法,观察203例结肠癌、癌旁黏膜和66例转移淋巴结的IMP3表达.结果 IMP3在结肠癌中的表达高于正常黏膜,与临床分期、T分期、淋巴和远处转移、Ki-67相关.转移淋巴结的IMP3表达高于原发癌和正常黏膜.IMP3阳性患者术后5年无瘤生存率和总体生存率明显降低,IMP3是影响无瘤生存[风险比(HR)1.92;95%可信区间(CI)1.06～3.47;P＜0.05]和总体生存(HR 2.37;95%CI 1.2～4.7;P＜0.05)的独立预后因素.结论 IMP3在结肠癌的发生发展中起重要作用,可能是预测术后转移复发的标记物.

Expression of insulin-like growth factor- II mRNA-binding protein 3 in colon cancer and its implication

Objective To explore the expression and role of insulin-like growth factor-II mRNA-binding protein 3 (IMP3) in colon cancer. Methods IMP3 expression was detected by immunohisto-chemistry on tissue microarray, which containing 203 samples of primary colon cancer and adjacent normal mucosa, and 66 paired lymph node metastases ( LNM). Results IMP3 was up-regulated in colon cancer as compared with paired normal colonic mucosa and significantly correlated with clinical stage, T classification , LNM, distant metastasis and Ki-67 index. Immunoreactivity of IMP3 was significantly higher in LNM than in primary colon cancer and normal mucosa. The patients positive for IMP3 had lower 5-year disease-free survival (DFS) or overall survival (OS) than those negative for IMP3.IMP3 was an independent prognostic factor for DFS [ hazard ratio (HR) 1.92; 95% confidence interval (CI) 1.06-3.47 ;P <0.05] and OS (HR 3.37; 95% CI 1.24.7 ;P <0.05). Conclusion IMP3 might play an important role in colon cancer progression and be served as a biomarker to predict metastasis or recurrence after colonectomy.