Pure alexia after damage to the right fusiform gyrus in a right-handed male |
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| Affiliation: | 2. Institute of Sensory Analysis, Warsaw, Poland;1. Department of Neurology, Medical University of Warsaw, Mazowiecki Szpital Bródnowski, Warsaw, Poland;2. Department of Physiotherapy, Mazowiecki Szpital Bródnowski, Warsaw, Poland;1. Department of Neurosurgery, Military Institute of Medicine, Warszawa, Poland;2. Department of Pathology, Military Institute of Medicine, Warszawa, Poland;3. Department of Radiology, Military Institute of Medicine, Warszawa, Poland;1. Department of Communication Disorders, School of Psychological Science, Health Sciences University of Hokkaido, Ainosato 2-jo 5-chome, Kita-ku, Sapporo, 002-8072 Hokkaido, Japan;2. Department of Health Science, Faculty of Psychological and Physical Science, Aich Gakuin University, Aichi, Japan;3. Department of Social Welfare, Bukkyo University, Kyoto, Japan;1. Laboratory of Cognitive Neurorehabilitation, Faculty of Medicine, University of Geneva, Geneva, Switzerland;2. Division of Neurorehabilitation, Geneva University Hospitals, Geneva, Switzerland;3. Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland;1. Department of Neurosurgery, Medical University of Gdansk, Gdansk, Poland;2. Students’ Scientific Association, Neurosurgery Department, Medical University of Gdansk, Gdansk, Poland |
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| Abstract: | ![]()
Pure alexia refers to a rare acquired reading disorder commonly associated with damage to the posterior part of the left medial occipito-temporal (fusiform) gyrus, which is known as the visual word-form area (VWFA) and thought to be the neural basis for visual processing of letters and words. Right-sided lesions very rarely lead to pure alexia in right-handed individuals. We report a case of a 33-year-old right-handed man with isolated pure alexia resulting from a hemorrhagic lesion to the right fusiform gyrus. A limited recovery of reading skills was observed within six weeks post onset. During this period, the patient spontaneously developed a letter-by-letter reading strategy. Functional magnetic resonance imaging revealed right-hemisphere dominance for language as well as bilateral reading-related activity in the fusiform gyri. Our case indicates that pure alexia may arise as a consequence of damage to the right fusiform gyrus even in right-handed patients (who still may have right hemisphere dominance for language and reading skills), and may lead to a severe reading disorder, as in individuals with left-hemisphere dominance for language. |
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| Keywords: | Pure alexia Hemorrhagic stroke Fusiform gyrus Functional magnetic resonance imaging Laterality |
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