Statin-Mediated Low-Density Lipoprotein Lowering in Chronic Congestive Heart Failure |
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| Affiliation: | 1. Murray Ocular Oncology and Retina, Miami, Florida;2. Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida;3. Department of Ophthalmology, University of Puerto Rico, San Juan, Puerto Rico;4. Department of Surgery, Ponce Health Sciences University, Ponce, Puerto Rico;1. Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education, Department of Chemistry, Central China Normal University, Wuhan 430079, China;2. College of Food Science & Engineering, Wuhan Polytechnic University, Wuhan 430023, China;3. Hubei Collaborative Innovation Center for Processing of Agricultural Products, Wuhan 430023, China;1. Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan;2. Department of Endocrinology and Hypertension, Tokyo Women''s Medical University, Tokyo, Japan |
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| Abstract: | ![]()
Many theories and clinical trials have attempted to address the effect of low-density lipoprotein (LDL) lowering in chronic congestive heart failure (CHF). The current evidence suggests that there is no convincing reason for administering statins to patients with nonischemic heart failure. Although they do not reduce the mortality rate, statins reduce LDL cholesterol and may provide some benefit to patients with ischemic heart failure. in contrast, some authors believe that statin therapy may actually worsen outcomes in patients with CHF, especially if there is excessive reduction in LDL cholesterol. This review discusses the theories attempting to link the adverse effects of statin-mediated LDL lowering in CHF to increased levels of endotoxin or reduced levels of coenzyme Q10. In addition, the 2 largest randomized, double-blind, placebo-controlled clinical trials (CoRoNA and Gissi-HF) were discussed. it is clear that more trials are needed to definitely ascertain the effect of statins on CHF. |
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