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Myeloperoxidase levels predict accelerated progression of coronary atherosclerosis in diabetic patients: Insights from intravascular ultrasound |
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| Institution: | 1. Faculty of Medicine of Marília (FAMEMA), Marília, SP, Brazil;2. Department of Anatomy, Institute of Biosciences, Univ Estadual Paulista (UNESP), Botucatu, SP, Brazil;3. Department of Biological Sciences, School of Sciences, Univ Estadual Paulista (UNESP), Bauru, SP, Brazil;4. Department of Morphology, Institute of Biosciences, Univ Estadual Paulista (UNESP), Botucatu, SP, Brazil;5. Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil;1. Department of Life Science, College of Biomedical & Health Science, Konkuk University, Chungju 380-701, Republic of Korea;2. Department of Physiology, College of Medicine, Konkuk University, Chungju 380-701, Republic of Korea;3. Department of Biomedical Laboratory Science, College of Applied Science and Industry, Daejeon University, Daejeon 300-716, Republic of Korea;4. Il Hwa Co., Ltd., Ginseng Research Institute, Guri 471-711, Republic of Korea;1. Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, Chungju 380-701, Republic of Korea;2. Department of Biomedical Laboratory Science, College of Applied Science and Industry, Daejeon University, Daejeon 300-716, Republic of Korea;3. Department of Pathology, School of Medicine, Konkuk University, Chungju 380-701, Republic of Korea;4. Botanical Drug Laboratory, Korea Ginseng Research Institute, Korea Ginseng Corporation, Daejeon 300-716, Republic of Korea;5. Department of Urology, CHA Bundang Medical Center, CHA University, Seongnam 463-712, Republic of Korea;1. Centre for Preventive Medicine, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK;2. Department of Veterinary Clinical Studies, The Royal (Dick) School of Veterinary Studies and Roslin Institute, The University of Edinburgh, Easter Bush, Midlothian, Edinburgh EH25 9RG, UK;3. School of Veterinary Medicine, Faculty of Health and Medical Science, University of Surrey, Guildford, Surrey GU2 7TE, UK |
| Abstract: | ObjectiveWhile inflammation has been proposed to contribute to the adverse cardiovascular outcome in diabetic patients, the specific pathways involved have not been elucidated. The leukocyte derived product, myeloperoxidase (MPO), has been implicated in all stages of atherosclerosis. The relationship between MPO and accelerated disease progression observed in diabetic patients has not been studied.MethodsWe investigated the relationship between MPO and disease progression in diabetic patients. 881 patients with angiographic coronary artery disease underwent serial evaluation of atherosclerotic burden with intravascular ultrasound. Disease progression in diabetic (n = 199) and non-diabetic (n = 682) patients, stratified by baseline MPO levels was investigated.ResultsMPO levels were similar in patients with and without diabetes (1362 vs. 1255 pmol/L, p = 0.43). No relationship was observed between increasing quartiles of MPO and either baseline (p = 0.81) or serial changes (p = 0.43) in levels of percent atheroma volume (PAV) in non-diabetic patients. In contrast, increasing MPO quartiles were associated with accelerated PAV progression in diabetic patients (p = 0.03). While optimal control of lipid and the use of high-dose statin were associated with less disease progression, a greater benefit was observed in diabetic patients with lower compared with higher MPO levels at baseline.ConclusionsIncreasing MPO levels are associated with greater progression of atherosclerosis in diabetic patients. This finding indicates the potential importance of MPO pathways in diabetic cardiovascular disease. |
| Keywords: | Diabetes mellitus Myeloperoxidase Atheroma progression Intravascular ultrasound Coronary atherosclerosis CAD"} {"#name":"keyword" "$":{"id":"kwrd0040"} "$$":[{"#name":"text" "_":"coronary artery disease DM"} {"#name":"keyword" "$":{"id":"kwrd0050"} "$$":[{"#name":"text" "_":"diabetes mellitus EEM"} {"#name":"keyword" "$":{"id":"kwrd0060"} "$$":[{"#name":"text" "_":"external elastic membrane HDL"} {"#name":"keyword" "$":{"id":"kwrd0070"} "$$":[{"#name":"text" "_":"high-density lipoprotein hsCRP"} {"#name":"keyword" "$":{"id":"kwrd0080"} "$$":[{"#name":"text" "_":"high sensitivity C-reactive protein IVUS"} {"#name":"keyword" "$":{"id":"kwrd0090"} "$$":[{"#name":"text" "_":"intravascular ultrasound LDL"} {"#name":"keyword" "$":{"id":"kwrd0100"} "$$":[{"#name":"text" "_":"low-density lipoprotein MPO"} {"#name":"keyword" "$":{"id":"kwrd0110"} "$$":[{"#name":"text" "_":"myeloperoxidase PAV"} {"#name":"keyword" "$":{"id":"kwrd0120"} "$$":[{"#name":"text" "_":"percent atheroma volume |
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