近10余年中医药治疗骨质疏松的回顾性分析

目的 分析近10余年来中医药治疗骨质疏松(osteoporosis，OP)的研究特点及趋势。方法 检索中国知网（CNKI）、维普(VIP)、万方(Wanfang)、Web of Science(WOS)、PubMed数据库，使用CiteSpace5.8.R3软件对近10余年中医药治疗骨质疏松文献进行国家、机构、作者、关键词等内容的可视化分析。结果 最终纳入中文文献2577篇，英文文献851篇，显示近10余年来发文量呈波动上升趋势；发表相关文献最多的国家是中国，而中心性最大的是日本；发表中文和英文文献量最多的作者分别是郑洪新和JiakeXu；研究热点主要集中于单味中药、中药复方、细胞分化、骨密度等。结论 基因差异表达、中药活性成分、信号通路、中西医结合将成为未来研究OP的热点及趋势。

Retrospective analysis of the treatment of osteoporosis with traditional Chinese medicine in the recent 10 years

Objective To analyze the research characteristics and trends of the treatment of osteoporosis (OP) with traditional Chinese medicine in the recent 10 years. Methods The databases of China National Knowledge Infrastructure (CNKI), VIP (VIP), Wanfang (Wanfang), Web of Science (WOS), and PubMed were searched. Visual analysis of countries, institutions, authors, keywords, etc. was performed using a CiteSpace5.8. software. Results 2577 Chinese literature and 851 English literatures were finally included, showing a fluctuating upward trend in the number of published papers in the recent 10 years. The country that published the most relevant literature was China, while the one with the greatest centrality was Japan. The author who published the most Chinese and English literature was Zheng Hongxin and Jiake Xu, respectively. The research hot spots mainly focused on single traditional Chinese medicine, traditional Chinese medicine compound, cell differentiation, and bone mineral density, etc. Conclusion Gene differential expression, active components of traditional Chinese medicine, signaling pathways, and integration of traditional Chinese and Western medicine may become the hot spots and trends in the future research on OP.