Hyaline vascular Castleman's disease (HVCD) mimicking lung metastasis of renal carcinoma: A case report and literature review |
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| Affiliation: | 1. Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China;2. Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China;3. National Clinical Research Center of Cancer, Tianjin, China;4. Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China;1. Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Saudi Arabia;2. Department of Pharmacology, Faculty of Medicine, Assiut University, Egypt;1. CNRS and Ecole Normale Supérieure de Paris, Laboratoire de météorologie dynamique, 24 Rue Lhomond, 75005 Paris, France;2. Applied Mechanics and Aerospace Engineering, Waseda University, Okubo, Shinjuku, Tokyo 169-8555, Japan;1. Institute of Mathematics, Polish Academy of Sciences, Śniadeckich 8, 00-656 Warszawa, Poland;2. Mathematical Sciences, University of Gothenburg, Mathematical Sciences, Chalmers University of Technology, SE-412 96 Göteborg, Sweden;1. Hematology Center Karolinska, Karolinska University Hospital Huddinge, Head: prof. dr med. Eva Hellström-Lindberg, Stockholm, Sweden;2. Department of Radiation Sciences, Section of Hematology, University of Umeå, Head: prof. dr med. Anders Wahlin, Umeå, Sweden;3. Department of Medicine, Sunderby Regional Hospital of Norrbotten County, Head: dr med. Birgitta Lauri, Luleå, Sweden;4. Centre of Hematology and Oncology, Children''s Hospital, Affiliate of Vilnius University Hospital Santariskiu Clinics, Head: doc. dr med. Lina Rageliene, Vilnius, Lithuania;5. Department of Clinical Pathology and Cytology, Karolinska University Hospital Huddinge, Head: prof. dr med. Mikael Björnstedt, Stockholm, Sweden;6. Department of Medicine at Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Head: prof. dr med. Jan Bolinder, Stockholm, Sweden |
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| Abstract: | Castleman's disease (CD) is a rare lymphoproliferative disorder characterized by atypical lymph node follicular hyperplasia. Subsequential occurrence of CD and cancers has been rarely reported and interpretations of the relationship are contentious. An asymptomatic 70-year-old man was found to have a left-sided hilar mass during routine follow-up after a radical right nephrectomy for clear cell carcinoma, raising suspicions of lung metastasis. Because there was no sign of recurrence in the original operative region, he underwent wedge resection of the left lung and lymph nodes dissection. Histology showed typical features of HVCD. Herein, we emphasize careful histopathology and complete resection of CD. We speculate that subsequential occurrence of CD and cancers may not be coincidental and warrants further exploration. |
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| Keywords: | Castleman's disease Renal cancer Complete resection Histopathology Occurrence |
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