| 氟尿嘧啶抗血管生成作用的实验研究 |
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| 引用本文： | 尹鸣,陈龙邦,耿怀成,臧静.氟尿嘧啶抗血管生成作用的实验研究[J].医学研究生学报,2004,17(5):395-397. |
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| 作者姓名： | 尹鸣 陈龙邦 耿怀成 臧静 |
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| 作者单位： | 南京军区南京总医院肿瘤科,江苏南京,210002 |
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| 摘 要： | 目的：探讨氟尿嘧啶(5-FU)的抗血管生成作用。方法：以人脐静脉内皮细胞(HUVEC)原代培养模型，MTT法测定5-FU对HUVEC增殖的影响；采用鸡胚尿囊膜血管形成模型(CAM模型)，观察5-FU对鸡胚尿囊膜新生血管的抑制作用。结果：5-FU在非细胞毒浓度下可在体外抑制HUVEC的增殖，在体内抑制鸡胚尿囊膜新生血管形成。结论：5-FU在非细胞毒浓度下具有抗血管生成作用。
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| 关 键 词： | 氟尿嘧啶 血管生成 人脐静脉内皮细胞 鸡胚尿囊膜血管形成模型 |
| 文章编号： | 1008-8199(2004)05-0395-03 |
| 修稿时间： | 2003年5月5日 |
The experimental study of 5-FU on inhibiting angiogenesis |
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| YIN Ming,CHEN Long bang,GENG Huai cheng,ZANG Jing.The experimental study of 5-FU on inhibiting angiogenesis[J].Bulletin of Medical Postgraduate,2004,17(5):395-397. |
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| Authors: | YIN Ming CHEN Long bang GENG Huai cheng ZANG Jing |
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| Abstract: | Objective:To investigate the antiangiogenesis ability of 5 FU. Methods:Human umbilical vein endothelial cells were cultured primarily in vitro and influence of 5 FU on HUVEC proliferation was evaluated by MTT method. Chick chorilallantoic membranes(CAM) model was used to check whether the neovascularization of CAM could be suppressed in vivo . Results:5 FU both inhibited proliferation of HUVEC in vitro and suppressed angiogenesis of CAM in vivo at none cytotoxic doses. Conclusion: 5 FU demonstrated antiangiogenesis ability without obvious cytotoxicity. |
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| Keywords: | FU Angiogenesis HUVEC Chick chorioallantoic membrane |
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