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Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma
Institution:1. Cancer Dynamics Laboratory, The Francis Crick Institute, London NW1 1AT, UK;2. Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK;3. Cancer Immunology Unit, Research Department of Hematology, University College London Cancer Institute, London WC1E 6DD, UK;4. Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London WC1E 6DD, UK;5. Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London NW1 1AT, UK;6. Retroviral Immunology, The Francis Crick Institute, London NW1 1AT, UK;7. Department of Bioinformatics and Biostatistics, The Francis Crick Institute, London NW1 1AT, UK;8. Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden Hospital, London SW3 6JJ, UK;9. Department of Pathology, the Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK;10. Department of Urology, the Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK;11. Department of Cellular Pathology, University College London Hospital, London NW1 2BU, UK;12. Translational Immune Oncology Lab, Centre for Molecular Pathology, The Royal Marsden Hospital, Sutton SM2 5PT, UK;13. Department of Pathology, Cruces University Hospital, Biocruces-Bizkaia Institute, 48903 Barakaldo, Bizkaia, Spain;14. Department of Cellular Pathology, Guy’s & St Thomas’ NHS Foundation Trust, St Thomas’ Hospital, London SE1 7EH, UK;15. Division of Research, Peter MacCallum Cancer Centre, Melbourne VIC 300, Australia;16. Department of Pathology, GZA-ZNA Hospitals, Wilrijk, Antwerp, Belgium;17. Cancer Metastasis Laboratory, University College London Cancer Institute, London WC1E 6DD, UK;18. Department of Medical Oncology, University College London Hospitals, London NW1 2BU, UK;19. Division of Infection and Immunity, University College London, London WC1E 6BT, UK;20. University College London Cancer Institute, London WC1E 6DD, UK
Abstract:
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Keywords:clear cell renal cell carcinoma  nivolumab  anti-PD-1  T cell receptor  TCR clonal maintenance  TCR clonal replacement  human endogenous retrovirus  multiregion  autopsy
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