| 抗坏血酸对维持性血液透析氧化应激及微炎症状态的影响 |
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| 引用本文： | 丁琼,陈雷,阚明,吴永贵.抗坏血酸对维持性血液透析氧化应激及微炎症状态的影响[J].安徽医药,2010,14(3):328-330. |
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| 作者姓名： | 丁琼 陈雷 阚明 吴永贵 |
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| 作者单位： | 安徽医科大学第三附属医院肾内科,安徽,合肥,230061;安徽医科大学第一附属医院肾内科,安徽,合肥,230032 |
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| 摘 要： | 目的探讨大剂量抗坏血酸对维持性血液透析患者氧化应激及微炎症的影响。方法该院血液净化中心MHD患者60例，分为抗坏血酸治疗组30例和非治疗组30例，治疗组每次透析开始给予抗坏血酸持续静脉滴注至透析结束，治疗3月。非治疗组30例未给予抗坏血酸静脉滴注。20例对照组为健康体检者。测定MHD患者透析前后及治疗前后血浆丙二醛含量（MDA）、超氧化物歧化酶活力（SOD）、血浆抗坏血酸含量、超敏C反应蛋白（Hs—CRP）。结果MHD组血浆MDA含量、血清HsCRP明显高于对照组（P〈0．01），SOD、抗坏血酸含量明显低于对照组（P〈0．01）。MHD组治疗组治疗后血浆MDA含量、血清HsCRP低于治疗前（P〈0．05），而血清SOD、抗坏血酸含量高于治疗前（P〈0．05，P〈0．01）。3月后治疗组与未治疗组相比，血浆MDA含量、血清HsCRP降低（P〈0．05，P〈0．01），但仍高于对照组。而SOD、抗坏血酸含量升高（P〈0．01）。结论MHD患者体内存在OS、微炎症状态，抗氧化剂抗坏血酸能有效改善MHD患者OS及微炎症状态。
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| 关 键 词： | 维持性血液透析 动脉硬化 抗坏血酸 氧化应激 微炎症状态 |
Effect of ascorbic acid on ameliorating oxidative stress and micro inflammation state in maintenance hemodialysis patients |
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| DING Qiong,CHEN Lei,KAN Ming,WU Yong-gui.Effect of ascorbic acid on ameliorating oxidative stress and micro inflammation state in maintenance hemodialysis patients[J].Anhui Medical and Pharmaceutical Journal,2010,14(3):328-330. |
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| Authors: | DING Qiong CHEN Lei KAN Ming WU Yong-gui |
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| Institution: | 1.Department of Nephropathy;The Third Affiliated Hospital;Anhui Medical University;Hefei 230061;2.The First Affliated Hospital;Anhui Medical Univercity;Hefei 230032 |
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| Abstract: | Aim To evaluate the effect of ascorbic acid on ameliorating oxidative stress and micro inflammation state in maintenance hemodialysis patients(MHD).Methods The study collected 60 cases of MHD patients from blood purification center of Hefei No.1 People's Hospital and 20 cases of healthy individuals as control group.30 cases of MHD received ascorbic acid continuous intravenous infusion from the beginning to the end in each dialysis during 3-month treatment while the other 30 cases of MHD did not have ascorbi... |
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| Keywords: | maintenance hemodialysis atherosclerosis ascorbic acid oxidative stress micro inflammation state |
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