| 复方感冒合剂对孕鼠及胎鼠生理指标的影响 |
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| 引用本文： | 张敏,谢靳.复方感冒合剂对孕鼠及胎鼠生理指标的影响[J].湖北中医学院学报,2009,11(5):15-18. |
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| 作者姓名： | 张敏 谢靳 |
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| 作者单位： | 湖北中医学院;湖北省中医院; |
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| 摘 要： | 目的观察复方感冒合剂对孕鼠及胚胎发育毒性的影响。方法将50只SD孕鼠随机分为5组,即复方感冒合剂高(13.0g/kg)、中(6.5g/kg)、低(3.3g/kg)3个剂量组、阴性对照组和阳性对照组,每组10只,在大鼠受孕的第7-16天分别灌胃给予复方感冒合剂、生理盐水和新康泰克,所有孕鼠在妊娠的第20天处死,剖腹取子宫称重,记录总胎数、吸收胎数、死胎数和活胎数;测量并记录活胎鼠体重、身长和尾长,并检查胎鼠外观有无异常;每窝50%的活胎鼠经茜素红和阿利新蓝染色后做骨骼检查,50%用Bou in液固定后做内脏检查。结果复方感冒合剂各剂量组孕鼠的体重增加、生殖能力,胎鼠的体重、身长和尾长等生理指标的变化与阴性对照组比较差异无统计学意义(P>0.05);且各剂量组与阴性对照组比较,胎鼠的外规、骨骼、内脏发育均未见明显畸形,差异无统计学意义(P>0.05)。结论在本实验室条件下,复方感冒合剂各剂量均无明显母体毒性、胚胎毒性和致畸性,且在实验剂量范围内,复方感冒合剂未呈现剂量反应关系。
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| 关 键 词： | 复方感冒合剂 致畸性 胚胎毒性 |
Influences of Fufang Ganmao Mixture (Compound Mixture for Common Cold) on Physiological Indexes of Pregnant and Embryonic Rats |
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| ZHANG Min,XIE Jin.Influences of Fufang Ganmao Mixture (Compound Mixture for Common Cold) on Physiological Indexes of Pregnant and Embryonic Rats[J].Journal of Hubei College of Traditional Chinese Medicine,2009,11(5):15-18. |
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| Authors: | ZHANG Min XIE Jin |
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| Institution: | 1.Grade 2006 postgraduate student;Hubei University of Chinese Medicine;Wuhan 430061;Hubei;2.Hubei Hospital of Traditional Chinese Medicine;Hubei |
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| Abstract: | Objective To observe the toxic influences of Fufang Ganmao Mixture(Compound Mixture for Common Cold) on pregnant rats and embryonic development.Method 50 SD pregnant rats were randomly divided into 5 groups: 3 Fufang Ganmao Mixture groups(high dose,at 13.0g/kg;medium dose,at 6.5g/kg and low dose,at 3.3g/kg),negative control group and positive control group.Each group was made up of 10 rats,which were given Fufang Ganmao Mixture,normal saline and CONTAC NT(compound pseudoephedrine hydrochloride sustained-rel... |
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