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Phentolamine prevents the somatostatin-mediated inhibition of pancreatic glucagon secretion. |
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| Authors: | P H Smith S C Woods J W Ensinck D Porte |
| Affiliation: | 1. Division of Metabolism, Seattle Veterans Administration Hospital, Seattle, Wash., USA;2. the Department of Medicine, University of Washington, Seattle, Wash., USA;3. the Department of Biological Structure, University of Washington, Seattle, Wash., USA;4. the Department of Psychology, University of Washington, Seattle, Wash., USA |
| Abstract: | This study was undertaken to assess the role of alpha-adrenergic receptors in the somatostatin-mediated inhibition of pancreatic glucagon secretion. In dogs, somatostatin inhibited the pancreatico-duodenal vein output of glucagon. During an infusion of the alpha-adrenergic blocking agent phentolamine, somatostatin did not significantly inhibit the output of glucagon. Thus, alpha-adrenergic mechanisms appear to influence the ability of somatostatin to decrease pancreatic glucagon secretion. |
| Keywords: | Reprint requests should be addressed to Phillip H. Smith Ph.D. Seattle Veterans Administration Hospital 4435 Beacon Ave. So. Seattle Wash. 98108. |
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