甲状腺肿瘤CD44V6的表达及其意义

目的探讨甲状腺肿瘤中CD44V6的表达及意义。方法免疫组化检测100例甲状腺癌（淋巴结转移阳性50例，阴性50例）以及20例甲状腺腺瘤中CD44V6的表达。结果甲状腺癌组CD44V6的阳性表达率为72％，显著高于甲状腺良性腺瘤组的20％；淋巴结转移组CD44V6的阳性表达率为90％，显著高于无转移组的54％；不同病理类型、临床分期和生存期甲状腺癌中CD44V6的阳性表达率明显不同。结论CD44V6在甲状腺良恶性肿瘤的鉴别诊断，甲状腺癌淋巴结转移与否的判断和预后估计等方面有重要意义。

Expression and significance of CD44V6 in thyroid neoplasms

Objective To investigate the expression of CD44V6 in thyroid neoplasms and its significance. Methods The expression of CD44V6 in paraffin-embeded thyoid carcinoma tissue from 100 patients (50 with lymph node metastasis,50 without) and 20 patients with thyroid adenoma was measured by immunohistochemistry staining. Results Positive expression of CD44V6 in the group of thyoid carcinoma was 72%, significantly higher than the group of thyroid adenoma.Positive expression of CD44V6 in the group of thyoid carcinoma with lymph node involvement was 90%,significantly higher than the group of thyoid carcinoma without lymph node involvement.In patients with different pathological grade,different clinical stage and different survival time, the positive expression of CD44V6 was significantly different. Conclusions The results suggest that CD44V6 can be regarded as an valuable molecular markers to distinguish benign thyroid tumor from malignant tumor, to predict lymph node metastasis and prognosis.