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A defective proviral DNA with a 2.6-kb deletion of human immunodeficiency virus type 1 (HIV-1) in a persistently HIV-1 infected cell clone |
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| Authors: | Hideki Imai Kumiko Maotani-Imai Yeon-Sil Shin Kazuyoshi Ikuta Seishi Suehiro Takashi Kurimura Shiro Kato Kanji Hirai |
| Affiliation: | (1) Section of Serology, Institute of Immunological Science, Hokkaido University, Sapporo, Japan;(2) Department of Cell Biology and Microbiology, Division of Biochemistry, Institute of Bio-Active Science, Nippon Zoki Pharmaceutical Co., Ltd., Hyogo, Japan;(3) Department of Pathology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan;(4) Department of Cell Regulation, Division of Virology and Immunology, Medical Research Institute, Tokyo Medical and Dental University, Yushima, Tokyo, Japan |
| Abstract: | A cell line (H2-5) producing defective doughnut-shaped particles of human immunodeficiency virus type 1 (HIV-1) was found to contain proviral DNA with a large deletion of 2558 bases, corresponding to the 3  half ofpol gene, the entirevif andvpr genes, and the 5 terminal of thetat gene. |
| Keywords: | HIV-1 H2-5 cells defective proviral DNA MT-4 cells HTLV-I PCR |
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