可溶性转铁蛋白受体与血清铁蛋白在慢性炎症性疾病合并缺铁性贫血诊断中的价值比较

目的：探讨可溶性转铁蛋白受体（Soluble tranferrin receptor,sTfR）与血清铁蛋白（Serum ferritin,SFer）在慢性炎症性疾病合并缺铁性贫血（Iron deficiency anemia,IDA）诊断中的价值。方法：随机选取我院2009年8月至2011年6月收治的29例患有慢性炎症性疾病伴IDA患者,31例慢性炎症性疾病无贫血患者,以及28例健康人,进行SFer,sTfR检测。结果：sTfR在慢性炎症性疾病合并IDA组明显升高,与慢性炎症性疾病无贫血组比较有显著性差异（P〈0.01）;SFer在慢性炎症性疾病合并IDA组有降低,与慢性炎症性疾病无贫血组比较无显著性差异（P〉0.05）。结论：血清sTfR的测定较SFer更能准确反映体内铁贮存情况,对慢性炎症性疾病合并IDA的诊断具有指导意义。

Comparison of soluble transferrin receptor and serum ferritin in the diagnosis of iron deficiency anemia accompanied by inflammatory disease

Objective： To analyze the significance of soluble transferrin receptor （sTIR） and serum ferritin （sFer） in the diagnosis of iron deficiency anemia （IDA） accompanied by inflammatory disease. Methods： Blood auto analysis, dipyridine eolorimetr, enzyme-hnked immunosorbent assay （ELISA） and biotin-avidin amplified ELISA were performed to determine the levels of hematoglobin and serum ferritin, and sTIR in 29 IDA patients with inflammatory disease, 31 inflammatory disease patients without anemia and 20 health controls. Results.. The level of sTIR in IDA patients with inflammatory disease was significantly higher than that in patients only with inflammatory disease （P〈0. 05）. ConclUsion： The level of serum sTIR can quickly and exactly reflect the condition of iron storage in the body and is helpful in the diagnosis of the IDA accompling by inflammatory disease.