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| 寻常型银屑病患者BMD、ALP、Ca、P、TRACP-5b的检测及其意义 | |
| 引用本文： | 杜华,许旭峰,陈克明,付学敬,窦莉莉.寻常型银屑病患者BMD、ALP、Ca、P、TRACP-5b的检测及其意义[J].临床军医杂志,2011,39(6). |
| 作者姓名： | 杜华 许旭峰 陈克明 付学敬 窦莉莉 |
| 作者单位： | 1. 解放军兰州军区兰州总医院皮肤科,甘肃兰州,730050 2. 甘肃中医学院,甘肃兰州,730000 3. 骨科研究所,甘肃兰州,730050 |
| 基金项目： | 甘肃省科技厅科技支撑项目(2010GS0511) |
| 摘 要： | 目的检测寻常型银屑病患者骨代谢生化指标及骨密度的情况,以了解寻常型银屑病患者的骨代谢异常状况。方法采用双能X线吸收法对48例寻常型银屑病患者(实验组)和40例健康对照者(对照组)行腰椎、股骨颈、左前臂骨密度检测;在相同条件下用贝克曼自动生化分析仪检测两组血液中ALP、Ca、P的浓度;ELSIA法检测两组血清中抗酒石酸酸性磷酸酶-5b(TRACP-5b)的浓度。结果寻常型银屑病患者血清TRACP-5b、ALP的浓度明显高于对照组(P<0.05),差异具有统计学意义;血清Ca浓度较正常对照组低,差异有统计学意义(P<0.05);血清P的浓度和正常对照组比较差异无统计学意义(P>0.05),腰椎、股骨颈、左前臂的骨密度及T值与对照组比较,具有统计学意义(P<0.05)。结论寻常型银屑病患者骨形成和骨吸收相关酶较正常人的血清水平升高,骨密度较正常人降低,说明寻常型银屑病患者骨代谢异常并已致骨量减少。血钙异常可能是寻常型银屑病骨代谢异常的原因之一,而血P在寻常型银屑病骨代谢异常中无影响。 |
| 关 键 词： | 寻常型银屑病 骨密度 骨代谢 |
The test and meaning of BMD,ALP,Ca,P,TRACP-5b in psoriasis vulgaris patients |
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| Du Hua,Xu Xu-feng,Chen Ke-ming,Fu Xue-jin,Dou Li-li.The test and meaning of BMD,ALP,Ca,P,TRACP-5b in psoriasis vulgaris patients[J].Clinical Journal of Medical Officer,2011,39(6). | |
| Authors: | Du Hua Xu Xu-feng Chen Ke-ming Fu Xue-jin Dou Li-li |
| Institution: | Du Hua1,Xu Xu-feng2,Chen Ke-ming3,Fu Xue-jing2,Dou Li-li2(1.Department of Dermatology,Lanzhou General Hospital of Lanzhou Command,PLA,Lanzhou Gansu 730050,China,2.Gansu College of Traditional Chinese Medicine,Lanzhou Gansu 730000,3.Institute of Orthopaedics,China) |
| Abstract: | Objective To check the biochemical markers and bone mineral density of the patients which was diagnosed as psoriasis vulgaris and to know the bone metabolic abnormal conditions of psoriasis. Methods The 48 patients which were diagnosis as psoriasis vulgaris(experimental group) and 40 healthy controls(control group) were checked the bone mineral density of lumbar spine,femoral neck and the left forearm by dual energy x-ray absorptiometry;both of the two groups were checked the concentration of ALP,P and Ca i... |
| Keywords: | psoriasis vulgaris bone mineral density bone metabolism |
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