多指标综合评分法优化花芪通脉颗粒的提取工艺

目的优化花芪通脉颗粒的提取工艺。方法采用正交实验设计，以浸出物得率，灯盏乙素、延胡索乙素的含量为评定指标，用多指标综合评分法进行数据处理，优化提取条件。结果花芪通脉颗粒优化提取工艺为10倍量70 %乙醇，分2次回流提取，每次2 h。结论该提取工艺合理，有效成分提取效率高。

Optimization of the Extraction Technology for Huaqitongmai Granules with the Multiple Guidelines Grading Method

Objective To optimize the extraction technology for huaqitongmai granules(HTG). Methods An orthogonal test was adopted in the study.The rate of harvesting of the extract,the contents of scutellarin-7-0-glucuronide and tetrahydropalmatine were used as indices of appraisal.Data processing was carried out with the multiple guidelines grading method for optimizing the extraction condition. Results The optimized extraction technology for huaqitongmai granules was shown to be: a tenfold volume of 70 % alcohol should be added to 1 volume of the granules for 2 successive reflux extractions each of which lasting 2 h. Conclusion The optimized extraction technology was rational and the extraction rate of the active principles was high.