| 桃红四物汤抗血小板活化作用及机制研究 |
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| 引用本文： | 韩岚,彭代银,许钒,汪宁,刘青云,戴敏,刘冬. 桃红四物汤抗血小板活化作用及机制研究[J]. 中国中药杂志, 2010, 35(19): 2609-2612 |
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| 作者姓名： | 韩岚 彭代银 许钒 汪宁 刘青云 戴敏 刘冬 |
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| 作者单位： | 安徽省高等学校省级现代中药重点实验室,安徽中医学院,安徽合肥230038 |
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| 基金项目： | 教育部骨干教师计划项目(教科技[2000]17号) |
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| 摘 要： | 目的:探讨桃红四物汤(Taohong Siwu decoction,TSD)的抗血小板活化作用及机制。方法:采用旋转玻球法测定血小板黏附率;比浊法测定ADP,Adr诱导的血小板聚集率;建立血瘀模型,RIA法测定血浆TXB2,6-keto-PGF1α含量,ELISA法测定血浆VWF,GMP-140含量。结果:TSD能有效降低大鼠血小板黏附率,对ADP,Adr所诱导的大鼠血小板聚集具有明显抑制作用,对于血瘀大鼠,TSD显著降低血瘀大鼠血浆中TXB2,VWF,GMP-140水平,有增强6-keto-PGF1α血浆水平的趋势。结论:TSD具有较好的抗血小板活化的作用,且显示出多途径、多靶点的特点。
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| 关 键 词： | 桃红四物汤 血小板活化 血小板黏附 血小板聚集 血小板释放 |
| 收稿时间： | 2009-12-17 |
Studies on anti-platelet activation effect and partial mechanisms of Taohong Siwu decoction |
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| HAN Lan,PENG Daiyin,XU Fan,WANG Ning,LIU Qingyun,DAI Min and LIU Dong. Studies on anti-platelet activation effect and partial mechanisms of Taohong Siwu decoction[J]. China Journal of Chinese Materia Medica, 2010, 35(19): 2609-2612 |
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| Authors: | HAN Lan PENG Daiyin XU Fan WANG Ning LIU Qingyun DAI Min LIU Dong |
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| Affiliation: | Key Laboratory of Chinese Medicine Research and Development in Anhui Province, Anhui College of Traditional Chinese Medicine, Hefei 230038, China;Key Laboratory of Chinese Medicine Research and Development in Anhui Province, Anhui College of Traditional Chinese Medicine, Hefei 230038, China;Key Laboratory of Chinese Medicine Research and Development in Anhui Province, Anhui College of Traditional Chinese Medicine, Hefei 230038, China;Key Laboratory of Chinese Medicine Research and Development in Anhui Province, Anhui College of Traditional Chinese Medicine, Hefei 230038, China;Key Laboratory of Chinese Medicine Research and Development in Anhui Province, Anhui College of Traditional Chinese Medicine, Hefei 230038, China;Key Laboratory of Chinese Medicine Research and Development in Anhui Province, Anhui College of Traditional Chinese Medicine, Hefei 230038, China;Key Laboratory of Chinese Medicine Research and Development in Anhui Province, Anhui College of Traditional Chinese Medicine, Hefei 230038, China |
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| Abstract: | |
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| Keywords: | Taohong Siwu decoction platelet activation platelet adhesion platelet aggregation platelet releasion |
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