Cytotoxic constituents from the roots ofAnthriscus sylvestris |
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| Authors: | Young-Hee Lim Moon-Jeong Leem Dong-Hyuk Shin Hwan-Bong Chang Seung-Woo Hong Eun-Yi Moon Dug-Keun Lee Sung-June Yoon Won-Sick Woo |
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| Affiliation: | R&D Centre, Dong-wha Pharmaceutical Ind. Co., Ltd, Anyang City, Korea. |
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| Abstract: | Activity-guided fractionation of the roots of Anthriscus sylvestris resulted in the isolation and characterization of five cytotoxic compounds, deoxypodophyllotoxin (1), falcarindiol (2), and angeloyl podophyllotoxin (5) from the hexane soluble fraction and morelensin (3), bursehernin (4) from the chloroform soluble fraction. It is the first report of the occurrence of compound 5 in nature. |
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| Keywords: | Anthriscus sylvestris Anti-tumour agents Cytotoxic lignans Angeloyl podophyllotoxin |
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