体外放射联合高剂量率后装治疗鼻咽癌的临床研究

目的 观察体外放射联合高剂量率后装在治疗鼻咽癌中的疗效和并发症。方法 1997年5月至1998年12月采用^60Co体外放射联合高剂量率腔内后装治疗鼻咽癌30例。结果 全部病例都随访4年,2例鼻咽局部复发。4年局部控制率为93．3%(28／30),远处转移8例,张口困难3例,无1例病人发生硬软腭穿孔。结论 联合后装腔内放射治疗,增加鼻咽腔内照射剂量,有利于提高局部控制率,联合后装腔内放疗还可以适当减少鼻咽癌外照射剂量,有利于降低张口困难的发生率。

Clinical study of nasopharyngeal carcinoma treated by combined external irradiation and intracavitary brachytherapy of the high dose rate

Objective The results and side effects of nasopharyngeal carcinoma treated by combined external irradiation and intracavitary brachytherapy of the high dose rate were studied. Methods From May 1997 to December 1998,30 patients with nasopharyngeal carcinoma were treated by 60 Co external irradiation plus intracavitary brachytherapy of the high dose rate.Results All patients were followed up for 4 years.The 4-year local control rate was 93 3%,2 cases recurred in the nasopharynx,8 cases developed distant metastases,3 cases developed trismus.No cases occurred perforations in hard and soft palate.Conclusion External irradiation plus intracavitary brachytherapy for nasopharyngeal carcinoma is indicated for boosting the dose to the nasopharyngeal cavity;reducing the dose for external irradiation.It can improve local control rate of nasopharyngeal carcinoma and reduce occur rate for the trismus.