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| 巨细胞病毒特异性IgG抗体亲和力测定及其临床意义 | |
| 引用本文： | 李革,熊杰,刘志峰. 巨细胞病毒特异性IgG抗体亲和力测定及其临床意义[J]. 中国实用儿科杂志, 2001, 16(3): 162-164 |
| 作者姓名： | 李革 熊杰 刘志峰 |
| 作者单位： | 华中科技大学同济医学院附属同济医院儿科临床病毒室 |
| 摘 要： | 目的 |
| 关 键 词： | 巨细胞病毒 |
| 文章编号： | 1005-2224(2001)03-0162-03 |
| 修稿时间： | 2000-10-30 |
Measurement of specificIgG avidity for verification of recent primary cytomegalovirus infection |
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| Li Ge,XIONG Jie,Liu Zhifeng. Measurement of specificIgG avidity for verification of recent primary cytomegalovirus infection[J]. Chinese Journal of Practical Pediatrics, 2001, 16(3): 162-164 | |
| Authors: | Li Ge XIONG Jie Liu Zhifeng |
| Affiliation: | Li Ge,Xiong Jie,Liu Zhifeng.Department of Pediatrics,Tongji Hospital of Tongji Medical College,Huazhong Science and Technology University,Wuhan 430030 |
| Abstract: | Objective To distinguish primary CMV infection from reactivation or reinfection.Methods A urea denaturation test was included in the washstep of the standard IgG ELISA in 12 patients of age<12 whose serum CMV-IgG were positive,avidity indexes of CMV-IgG were measured.Results Among children aged 1~12 years,the varieties of avidity indexes of CMV-IgG in A group(IgM negative and IgG positive) and B group(IgM positive and IgG positive) had the same trend.There was only one case in B group whose avidity index was under 30%,the other were all above 30%,and most were above 50%.But among 40 children aged 1~12 months,the avidity indexes were under 30% in 21 cases,8 cases were 30~50%,and 11 cases were above 50%.The antibody avidity in 1~6 months children was influenced by their mother's IgG,80%(12/15) of 7~12 months children had low-avidity antibodies.Conclusion CMV infection mostly occurred among 1~12 months children.Urea denaturation test was an efficient method to distinguish primary CMV infection from reactivation or reinfection. |
| Keywords: | Cytomegalovirus IgG antibody Avidity index |
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