早期乳腺癌保乳手术与改良根治术的临床疗效及生活质量比较

目的:比较保乳手术与改良根治术治疗早期乳腺癌的临床效果及生活质量。方法:回顾性分析2004年4月—2007年4月经保乳手术治疗的95例(保乳组)早期乳腺癌患者临床资料,并与同期行改良根治术95例(改良组)早期乳腺癌患者进行对比。结果:保乳组与改良组的局部复发率、转移率、生存率间无统计学差异(P>0.05);保乳组和改良组乳房外观美学效果"优良"率分别为93.7%和0(P<0.05);保乳组术后5年存活患者生活质量评分亦明显高于改良组(83.66±3.70 vs.73.07±4.85)(P<0.05)。结论:对于早期乳腺癌,保乳手术在获得与改良根治术相同疗效的同时,能明显改善患者术后的生活质量;掌握好保乳手术适应证、规范的手术切除和术后个体化综合治疗是手术成功的关健。

Breast-conserving surgery versus modified radical mastectomy for early breast cancer: clinical efficacy and quality of life

Objective: To compare the impacts between breast-conserving surgery and modified radical treatment on clinical efficacy and quality of life in patients with early breast cancer. Methods: The clinical data of 95 patients with early breast cancer undergoing breast-conserving therapy(breast-conserving group) between July 2004 and July 2007 were analyzed,and were compared with those of 95 matched patients over the same period undergoing modified radical mastectomy(modified radical group). Results: There were no significant differences between the two group in recurrence,metastasis and survival rate(all P>0.05).The rate of aesthetically excellent breast shape in breast-conserving group and modified radical group was 93.7% and 0,respectively(P<0.05).The quality-of-life score of the 5-year survival patients in breast-conserving group was significantly higher than that in modified radical group(83.66±3.70 vs.73.07±4.85)(P<0.05). Conclusion: In early breast cancer patients,breast-conserving surgery can achieve the same therapeutic efficacy as modified radical mastectomy,and meanwhile significantly improve their quality of life.Strict observation of the indications,standardized surgical resection and individualized,comprehensive postoperative management are critical to success of breast-conserving treatment.