急性梗阻肾损伤MRI研究进展

急性梗阻肾损伤是由尿路梗阻引起的肾功能下降,早期大部分患者除肾绞痛外,缺乏特定的体征或症状,而临床常用的实验室指标血清肌酐早期评价肾功能缺乏敏感性,且无法测量单肾功能改变,但治疗延迟会导致不可逆的肾损伤。随着磁共振成像技术不断发展,MRI不仅能明确泌尿系梗阻点,梗阻原因及梗阻程度,同时对梗阻后继发的早期病理生理变化非常敏感,且能定量准确评估单肾功能改变,使大多数病例通过早期诊断,早期干预得以纠正。解剖及功能的一站式扫描使MRI成为代替各种有创评估梗阻肾脏功能的非侵入性方法。

Research progresses in MRI in acute obstructive kidney injury

Acute obstructive kidney injury refers to a decline in renal function caused by urinary tract obstruction.In early stage,most patients lack specific signs or symptoms other than renal angina.However,clinical common laboratory indexes,such as serum creatinine,are used to evaluate whether the sensitivity of renal function is lower,but unable to measure the changes of single renal function.Nevertheless,treatment delay can lead to irreversible renal injury.Along with the development of magnetic resonance imaging,MRI can not only identify the site,cause and degree of urological obstruction,but also be sensitive to the secondary pathophysiological changes after the urinary obstruction in the early stage.It can quantitatively and accurately evaluate the changes of single renal function.Therefore,most patients can be corrected through early diagnosis and intervention.MRI has become a substitute of non-invasive methods for evaluating the renal function after urinary tract obstruction via one-stop scanning of anatomy and function.