痤疮患者外周血IL-6、TNF-α表达水平及其与痤疮严重程度的相关性研究

 

目的: 检测痤疮患者外周血中IL-6、TNF-α表达水平,并分析两者与痤疮严重程度的相关性。方法：收集我院皮肤科门诊诊治的寻常痤疮患者114例,其中轻度35例、中度43例、重度36例,另选择同时期健康体检者30例作为对照组。使用化学发光法检测治疗前及治疗后4周血清中IL-6、TNF-α的水平,并对结果进行比较分析。结果：轻、中、重度痤疮患者外周血中IL-6水平差异有统计学意义（P<0.01）,而TNF-α水平无明显差异（P=0.243）。轻度、中度、重度患者IL-6水平均高于对照组（P值均<0.05）,而不同严重程度患者组间IL-6水平差异无统计学意义（P值均>0.05）。痤疮严重程度与IL-6、TNF-α水平均无明显相关性（P值均>0.05）。 结论：IL-6参与了痤疮的炎症反应,但不能用于评估痤疮病情的严重程度。TNF-α与痤疮之间的关系仍需进一步深入研究。

Study of the correlation between the expression levels of IL-6 and TNF-α, and the severity of acne in acne patients

Objective： To assess the correlation of IL-6 and TNF-α levels and the severity of acne. Methods:Blood samples were collected from 30 normal controls and 114 patients with acne vulgaris before and after 4-week treatments. According to the severity of acne, patients were divided into mild, moderate and severe groups. Chemilunescence was used to measure expression levels of IL-6 and TNF-α.Rusults:The expression levels of IL-6, but not TNF-α, in patients with acne were significantly higher than that in the controls (for IL-6, P<0.01; for TNF-α, P=0.243). However, there were no differences in IL-6 levels among three acne groups (all P>0.05). Expression levels of IL-6 and TNF-α were not correlated with the severity of acne (both P>0.05).Conclusions:IL-6 is involved in the inflammatory response in acne, but cannot serve as an indicator of disease severity. Further study is needed to determine the relationship between TNF-α and acne.