Abstract: | Objective To evaluate the influence of coagulation indexes on the severity and prognosis of patients with craniocerebral injury.Methods A total of 113 patients with craniocerebral injury admitted to our hospital from October 2016 to December 2019 were selected as research objects.Coagulation indexes (PT,APTT,D-dimer,FIB,PLT and DIC scores) of all patients were detected at admission and 3 months after injury.Patients were divided into mild group,moderate group and severe group according to Glasgow coma scale (GCS) score.The differences of coagulation function indexes of patients in each group were compared.According to GOS scores at 3 months after injury,the patients were divided into good prognosis group and poor prognosis group.Multivariate Logistic regression was used to analyze the independent risk factors affecting the prognosis of craniocerebral injury.Results PT was significantly prolonged.D-dimer and DIC scores were significantly increased in patients with mild,moderate and severe craniocerebral injury,with statistically significant differences (P<0.05).There were significant differences in PT,D-dimer and DIC scores among the three groups (P<0.05).There was no significant difference in APTT,FIB and PLT among patients with craniocerebral injury of different severity(P>0.05).Univariate analysis showed that the severity of disease at admission,GCS score,prolongation of PT and APTT,the increase of D-dimer and DIC score were the influencing factors leading to poor prognosis of patients with craniocerebral injury (P<0.05).The results of multivariate Logistic analysis showed that low GCS score,prolonged PT,increased D-dimer and DIC score were independent risk factors for poor prognosis of patients with craniocerebral injury (P<0.05).Conclusion Abnormal coagulation function indicators are closely related to the severity and prognosis of patients with craniocerebral injury.Clinically,patients'' condition can be judged according to the level of coagulation function,so that targeted diagnosis and treatment measures can be taken to improve the prognosis of patients. |