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| VEGF-C、VEGFR-3在大肠癌中的表达及与微淋巴管生成的关系 | |
| 引用本文： | 赵杨,王竹君,申兴斌,王军,王春阳. VEGF-C、VEGFR-3在大肠癌中的表达及与微淋巴管生成的关系[J]. 承德医学院学报, 2012, 29(3): 232-234. DOI: 10.3969/j.issn.1004-6879.2012.03.002 |
| 作者姓名： | 赵杨 王竹君 申兴斌 王军 王春阳 |
| 作者单位： | 1.承德医学院附属医院,河北承德,067000;2.承德医学院附属医院,河北承德,067000;3.承德医学院附属医院,河北承德,067000;4.承德医学院附属医院,河北承德,067000;5.承德医学院附属医院,河北承德,067000 |
| 摘 要： | 目的:探讨血管内皮生长因子-C(VEGF-C)及其受体(VEGFR-3)的表达与大肠癌发生及微淋巴管形成的关系.方法:采用免疫组织化学染色法检测20例大肠正常粘膜、20例大肠腺瘤、80例大肠癌组织VEGF-C、VEGFR-3的表达水平;并用D2-40标记微淋巴管,检测各组织的微淋巴管密度(LMVD).结果:大肠癌EGF-C、VEGFR-3阳性表达率明显高于大肠腺瘤和正常大肠黏膜(P＜0.05);大肠癌的LMVD值明显高于大肠腺瘤和正常大肠黏膜(P＜0.05).大肠癌VEGF-C、VEGFR-3的表达与LMVD值存在显著正相关(P＜0.01).结论:VEGF-C、VEGFR-3可能参与了大肠癌的 |
| 关 键 词： | 大肠癌 VEGF-C VEGFR-3 微淋巴管密度 免疫组织化学 |
VEGF-C, VEGFR-3 EXPRESSION IN COLORECTAL CARCINOMA AND RELATIONSHIPS BETWEEN GENESIS OF MICRO-LYMPHATIC VESSELS |
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| Affiliation: | ZHAO Yang,WANG Zhu-jun,SHEN Xing-bin,et al(Affiliated Hospital of Chengde Medical College,Hebei Chengde 067000,China) |
| Abstract: | Objective:To investigate the relationships between VEGF-C,VEGFR-3 expression in colorectal carcinoma(CC) and development of CC and genesis of micro-lymphatic vessels.Methods:Immunohistochemical staining was used to observe expression of VEGF-C,VEGFR-3 in 20 cases large intestine normal membrane(NM),20 cases large intestine adenoma(Ad) and 80 cases CC.The micro-lymphatic density(LMVD) of NM,Ad and CC were calculated by using D2-40 as the specif ic marker of lymphatic endothelium.Results:The VEGF-C,VEGFR-3 positive expression in CC,and LMVD of CC were obviously higher than that of NM and Ad(P< 0.05).Moreover,the expression of VEGF-C and VEGFR-3 in CC had obvious positive correlations with LMVD(P< 0.01).Conclusions:High expression of VEGF-C and VEGFR-3 may play an important role in development of CC.VEGF-C and VEGFR-3 may promote lymph node metastasis of CC by promoting genesis of micro-lymphatic vessels. |
| Keywords: | Colorectal carcinoma VEGF-C VEGFR-3 LMVD Immunohistochemistry |
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