中药何首乌饮对衰老大鼠抗氧化能力的影响

目的:观察何首乌饮对亚急性衰老大鼠血清丙二醛(MDA)含量、谷胱甘肽过氧化物酶(GSH-Px)和超氧化物歧化酶(SOD)活性以及总抗氧化能力(T-AOC)的影响.方法:30只雄性SD大鼠随机分为正常对照组、模型组和何首乌饮预防组,每组10只.D-半乳糖连续腹腔注射建立亚急性衰老大鼠模型,何首乌饮预防组大鼠在腹腔注射D-半乳糖的同时灌胃何首乌饮(0.06ml/kg),用药60d.分别检测各组大鼠血清MDA含量、GSH -Px活性、SOD活性及T-AOC.结果:与正常对照组大鼠比较,模型组大鼠MDA含量明显升高,GSH -Px活性、SOD活性、T-AOC明显降低(P＜0.01,P＜0.05)；与模

EFFECTS OF TRADITIONAL CHINESE MEDICINE HSWY ON ANTI-OXIDATIVE ABILITY OF SENILE RATS

Objective:To observe the effects of traditional Chinese medicine heshouwuyin(HSWY) on malondialdehyde(MDA) content,glutathione peroxidase(GSH-Px) activity,superoxide dismutase(SOD) activity and total antioxidative capacity(T-AOC) in serum of subacute senile rats.Methods:30 male SD rats were randomly divided into 3 groups,10 rats in each group: normal control group,senile model group and HSWY prevention group.The subacute senile rats model was made by intraperitoneal injection of D-gal continuous.The rats in HSWY prevention group were lavaged with HSWY(0.06ml/kg) for 60 days during injection of D-gal.The MDA content,GSH-Px activity,SOD activity and T-AOC in serum of rats in each group were respectively detected.Results:Compared with rats in normal control group,MDA content increased obviously,GSH-Px activity,SOD activity and T-AOC of rats in model group decreased obviously(P<0.01,P<0.05).Compared with rats in model group,MDA content decreased significantly,GSH-Px activity,SOD activity and T-AOC of rats in HSWY prevention group increased significantly(P<0.01).Conclusions:HSWY can inhibit declining of anti-oxidative ability of subacute senile rats,so has fairly anti-aging effects.