多西紫杉醇联合5-FU及CF治疗晚期胃癌24例疗效观察

目的:探讨多西紫杉醇联合氟尿嘧啶(5-FU)及亚叶酸钙(CF)治疗晚期胃癌的临床疗效及不良反应.方法:24例晚期胃癌患者给予多西紫杉醇、氟尿嘧啶(5-FU)、亚叶酸钙(CF)联合治疗,21-28天为1个周期,两个周期后评价疗效并观察患者生活质量改善情况和不良反应.结果:24例病人治疗总有效率为50％,患者的生活质量显著提高;毒副反应主要为恶心、呕吐、腹泻、脱发、白细胞减少及血小板抑制,无败血症和死亡病例.结论:多西紫杉醇联合5-FU及CF治疗晚期胃癌有较好的近期疗效,不良反应轻,患者易于耐受.

THERAPEUTIC EFFECTS OF DOCETAXEL COMBINED FLUOROURACIL AND CALCIUM FOLINATE IN TREATMENT OF 24 CASES LATE GASTRIC CANCER

Objective:To investigate the therapeutic effects and adverse reactions of docetaxel combined fluorouracil(5-FU) and calcium folinate(CF) in treatment of late gastric cancer.Methods:24 late gastric cancer patients were treated with docetaxel combined fluorouracil(5-FU) and calcium folinate(CF) for 2 treatment cycles(21-28 days as 1 cycle).The therapeutic effects,improvement of life quality and adverse reactions of patients were evaluated after 2 treatment cycles.Results:After treatment,the total effective rate was 50%,the life quality of patients improved obviously.The adverse reactions were mainly nausea,vomiting,diarrhea,baldness,leukopenia and platelet inhibition,no septicemia and deaths.Conclusions:Treating late gastric cancer with docetaxel combined fluorouracil(5-FU) and calcium folinate(CF) has better recent treatment results and light adverse reactions,and patients easy to tolerate.