卵巢幼年型颗粒细胞瘤临床病理观察

目的：探讨幼年型颗粒细胞瘤的临床病理学特点及诊断要点。方法：对2例幼年型颗粒细胞瘤进行临床资料、病理形态学及免疫组织化学观察,并结合文献对其诊断及鉴别诊断进行探讨。结果：2例镜下可见肿瘤细胞卵圆形或短梭形,胞质淡染,部分空泡状,成巢分布,呈多结节样生长,与周围卵巢组织有明显分界,局部区域有黏液样变性,血管丰富,部分细胞生长活跃,核分裂易见(5~7个/HPF),核沟不明显,未见Call-Exner小体。免疫组织化学染色结果：ER、PR、Vimentin和α-inhibit阳性,Ki-67增殖指数25%~40%不等。结论：卵巢幼年型颗粒细胞瘤是一种少见肿瘤,易与其他肿瘤混淆导致误诊,其临床病理特点应引起临床医师重视。

Clinicopathological observations of ovarian juvenile granulosa cell tumor

Objective: To explore the characteristics of clinicopathology and diagnostic criteria of ovarian juvenile granulosa cell tumor.Methods: The clinical data, histopathologic observation and immunohistochemical staining were studied in two cases of juvenile granulosa cell tumor.Results: Microscopic examination showed two cases of tumor was composed of ovoid cells or fusiform cells with cytoplasmic light dye, part of vacuolated with a nest. hTe multiple nodular growth and myxoid background with the surrounding ovary tissues which had a clear boundary were present. Blood vessels were rich with part of the cell growth. Mitosis often appears (5~7/HPF), nuclear groove was not obvious, and it did not see Call-Exner corpuscle. Immunohistochemically, revealed positivity for ER, PR, Vimentin and α-inhibit, and Ki-67 index ranges from 25% to 40%.Conclusion:Ovarian juvenile granulosa cell tumor is a rare tumor, and is easily confused with other tumor, leading to misdiagnosis. Clinicians should pay more attention on its clinicopathological characteristics.