| 肝细胞生长因子在缺血性疾病的研究及进展 |
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| 引用本文： | 吴文皋(综述),邓礼明,李林鹏,熊国祚(审校). 肝细胞生长因子在缺血性疾病的研究及进展[J]. 国际病理科学与临床杂志, 2016, 0(8): 1234-1238. DOI: 10.3978/j.issn.2095-6959.2016.08.036 |
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| 作者姓名： | 吴文皋(综述) 邓礼明 李林鹏 熊国祚(审校) |
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| 作者单位： | 南华大学附属第二医院血管外科,湖南 衡阳,421001 |
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| 基金项目： | Foundation item)湖南省教育厅青年基金(135104),湖南省自然科学基金(2015JJ2117),南华大学研究生创新基金项目(2016XCX46),湖南省自然科学基金和青年杰出基金(14JJ1024;2015JJ2117)。This work was supported by the Youth Fund of Hunan Province Department of Education(135104),the Natural Science Foundation of Hunan Province(2015JJ2117),Graduate Student Innovation Foundation of University of South China(2016XCX46),Hunan Province National Funds for Distinguished Young Scientists(14JJ1024 |
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| 摘 要： | 肝细胞生长因子(hepatocyte growth factor,HGF)是一类具有多功能生物活性的生长因子,参与机体多种组织器官及细胞的生长、再生、重塑、促血管新生等过程。因其具有生物活性的多样性,被广泛用于基础实验及临床研究,然而其对血管内皮细胞的增生及维护内皮细胞功能从而促进血管新生加速其侧枝循环作用,被广泛用于缺血性疾病的研究,本文就近年来HGF在缺血性疾病等方面进行综述。
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| 关 键 词： | 肝细胞生长因子 c-Met受体 HGF/c-Met信号途径 血管生成 下肢缺血 心肌梗死 |
Research and progress of hepatocyte growth factor in ischemic diseases |
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| Abstract: | Hepatocyte growth factor (HGF), which is a mesenchyme-derived pleiotropic factor, regulates the growth, regeneration, and remodeling of tissue organ and cells, and promotes angiogenesis. HGF is thoroughly researched for experimental or clinical purpose. HGF is also widely used in ischemic disease research for its activity in protecting the function of endothelial cells and promoting collateral circulation neovascularization. hTe purpose of this review is to summarize the present understanding of the therapeutic potential of HGF in ischemic diseases. |
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| Keywords: | hepatocyte growth factor (HGF) c-Met receptor HGF/c-Met signaling pathways angiogenesis lower limb ischemia myocardial infarction |
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