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| 伴CSF3RT618I突变的慢性粒单核细胞白血病1例并文献复习 | |
| 引用本文： | 王华,王志永,刘芳,辛春红,衣文婷,景瑞,尚应辉,董於坪,冯四洲. 伴CSF3RT618I突变的慢性粒单核细胞白血病1例并文献复习[J]. 国际病理科学与临床杂志, 2016, 0(9): 1463-1466. DOI: 10.3978/j.issn.2095-6959.2016.09.041 |
| 作者姓名： | 王华 王志永 刘芳 辛春红 衣文婷 景瑞 尚应辉 董於坪 冯四洲 |
| 作者单位： | 1. 滨州医学院烟台附属医院,山东 烟台,264100;2. 中国医学科学院北京协和医学院 血液学研究所血液病医院,天津,300020 |
| 基金项目： | 山东省自然科学基金(ZR2013HL001)；天津市应用基础与前沿技术研究计划(14JCZDJC33000)；滨州医学院科研启动基金(BY2012KYQD02)。@@@@Natural Science Foundation of Shandong Province(ZR2013HL001)，the Tianjin Application Foundation and Advanced Technology Research Program(14JCZDJC33000)，Scientific Research Fund of Binzhou Medical University(BY2012KYQD02)，P. R. China |
| 摘 要： | 目的：提高对伴CSF3RT618I突变的慢性粒单核细胞白血病(chronic myelomonocytic leukemia， CMML)的认识。方法：分析1例伴CSF3RT618I突变的CMML，结合文献复习讨论。结果：我们首次在CMML中报道CSF3RT618I突变。CSF3R突变的患者预后较差，酪氨酸激酶抑制剂能否改善其预后尚不清楚。结论：CSF3RT618I突变对CMML患者的预后影响还需要进一步临床研究来确定。 |
| 关 键 词： | 慢性粒单核细胞白血病 CSF3R突变 酪氨酸激酶抑制剂 |
A case report of chronic myelomonocytic leukemia with CSF3RT618I mutation |
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| Abstract: | Objective:To raise awareness of chronic myelomonocytic leukemia (CMML) with CSF3RT618I mutation. Methods: Analysis of a case of CMML with CSF3RT618I mutation, combined with literature review.Results: We first reported the CSF3RT618I mutation in CMML. The overall survival of patients with CSF3R mutations was low. The prognosis of the patients with tyrosine kinase inhibitors was not clear.Conclusion:The significance of CSF3RT618I mutation in CMML patients needs further clinical study. |
| Keywords: | chronic myelomonocytic leukemia (CMML) CSF3R mutation tyrosine kinase inhibitor |
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