CAPS评分对急性加重期慢性阻塞性肺疾病并无创通气患者远期预后评估

目的：探讨慢性阻塞性肺疾病和支气管哮喘生理评分(the COPD and asthma physiology score， CAPS)对慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease，AECOPD)并无创通气患者远期预后的评估效果。方法：以2014年6月至2015年10月在我院接受无创通气的AECOPD患者为观察对象，并根据其CAPS评分将其分为CAPS≥35组和CAPS<35组。比较不同CAPS评分患者出院时炎症细胞因子水平、肺功能和出院后1个月生活质量的差异。结果：CAPS≥35的患者出院时的CRP和IL-6等炎症细胞因子指标明显高于CAPS<35组患者，差异具有统计学意义(P<0.05)；出院时CAPS<35的患者肺功能指标明显优于CAPS≥35组，差异具有统计学意义(P<0.05)；治疗前，CAPS≥35组和CAPS<35组患者的生活质量各维度得分无明显差别，出院1个月时的调查结果显示：两组患者的生活质量均较治疗前增高，且CAPS<35组患者生活质量提高更明显(P<0.05)。结论：CAPS评分对AECOPD并无创通气患者的远期预后有较好的评估价值：CAPS评分高的患者病死率较高，预后较差。

The COPD and asthma physiology score of acute exacerbation of chronic obstructive pulmonary disease and noninvasive ventilation in patients with long-term prognosis evaluation

Objective:To investigate the effect of COPD and asthma physiology score (CAPS) on the long-term prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and mechanical ventilation. Methods:AECOPD patients receiving mechanical ventilation in our hospital from June 2014 to October 2015 were selected as objects. According to the CAPS score, which were divided into CAPS≥35 group and CAPS<35 group. hTe CAPS scores of different group were observed. hTe lung function and quality of life in different CAPS score group were compared after 1 month of treatment. Results: The level of CRP, IL-6 and other inflammatory cytokines index in patients with CAPS ≥35 at discharged was significantly higher than that of CAPS <35 groups, the difference was statistically significant (P<0.05); patients with CAPS <35 pulmonary function index was significantly better than that of patients with CAPS ≥35, the difference was statistically significant at discharge (P<0.05); before treatment, there was no significant difference in quality of life between the two groups. One month after discharge according to the results of the survey showed that the quality of life of two groups of patients were increased and CAPS <35 groups of patients quality of life improved more significantly (P<0.05). Conclusion: CAPS score has a high value in the long-term prognosis of patients with AECOPD and mechanical ventilation: high scores of patients with higher mortality, poor prognosis.