| 甘珀酸钠苦参碱包合作用的研究 |
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| 引用本文： | 戴小军,刘利军,梁斌.甘珀酸钠苦参碱包合作用的研究[J].中国药学杂志,2006,41(4):290-292. |
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| 作者姓名： | 戴小军 刘利军 梁斌 |
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| 作者单位： | 宁夏大学化学化工学院,银川,750021 |
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| 基金项目： | 国家高技术研究发展计划(863计划);宁夏大学校科研和教改项目 |
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| 摘 要： | 目的制备甘珀酸钠和苦参碱的包合物,研究甘珀酸钠和苦参碱的包合作用,测定了包合物的包合比。方法分别配制甘珀酸钠和苦参碱溶液,将两种溶液按不同比例混合,形成包合物。用X射线粉末衍射,红外光谱和核磁共振谱来表征包合物,用紫外可见分光光度法确定包合物的形成常数,用循环伏安法对包合物的电化学性质进行了研究。结果XRD,IR,1H-NMR等分析数据及熔点、比旋光度的变化确证了包合物的形成。结论甘珀酸钠和苦参碱可以形成1∶1的包合物。
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| 关 键 词： | 甘珀酸钠 苦参碱 包合物 循环伏安法 |
| 文章编号： | 1001-2494（2006）04-0290-03 |
| 收稿时间： | 2005-02-02 |
| 修稿时间： | 2005-02-02 |
Study on Inclusion Complex of Carbenoxolone Sodium with Matrine |
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| DAI Xiao-jun,LIU Li-jun,LIANG Bin.Study on Inclusion Complex of Carbenoxolone Sodium with Matrine[J].Chinese Pharmaceutical Journal,2006,41(4):290-292. |
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| Authors: | DAI Xiao-jun LIU Li-jun LIANG Bin |
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| Institution: | College of Chemistry and Chemical Engineering,Ningxia University,Yinchuan 750021,China |
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| Abstract: | OBJECTIVE To synthesize a new kind of inclusion complex involving carbenoxolone sodium(CS) and matrine(MT).(METHODS) The complex of carbemoxdone sodium with matrine was characterized by UV,IR,XRD and 1H-NMR.The stability constant of the inclusion complex of CS and MT in aqueous solution at 25 ℃ were calculated.RESULTS The stoichiometry of the inclusion complex appeared to be 1∶1.Using the cyclic voltammetry methods,the composition of the inclusion complex was comfirmed.CONCLUSION A novel crystalline structure of inclusion complex is formed.The data of IR and 1HNMR spectra also indicate the form of inclusion complex. |
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| Keywords: | carbenoxolone sodium matrine inclusion complex cyclic voltammograms |
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