Effect of omeprazole on delayed healing of acetic acid-induced gastric ulcers in rats |
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| Authors: | J Y Wang H Nagai S Okabe |
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| Institution: | Department of Applied Pharmacology, Kyoto Pharmaceutical University, Japan. |
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| Abstract: | Omeprazole, a gastric mucosal proton pump inhibitor, significantly and dose-dependently prevented the delayed healing of acetic acid-induced gastric ulcers in response to repeatedly administered indomethacin to rats. Both basal and histamine-stimulated gastric acid secretions in rats with acetic acid-induced ulcers that were given indomethacin were markedly and persistently (greater than 24 hr) inhibited after 4 weeks treatment with omeprazole. The prevention of delayed ulcer healing by omeprazole appears to be due to its long-lasting antisecretory activity. |
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