老年慢性阻塞性肺疾病患者肺功能和膈肌复合动作电位的相关性研究

目的初步探讨老年慢性阻塞性肺疾病（COPD）患者肺功能的变化与相关膈神经电生理改变的关系。方法分别对50例老年COPD患者和健康老年人进行肺功能及膈神经运动传导（PNC）、膈运动诱发电位（dMEP）及膈肌复合动作电位（dCMAP）检测。结果（1）50例老年COPD患者的呼吸功能状况显著低于非COPD健康老年人（P〈0．05）。（2）老年COPD组的PNC潜伏期平均值与健康老年人的差异无统计学意义（P〉0．05），dCMAP波幅的平均值显著低于健康老年人（P〈0．01）；老年COPD组的dMEP均正常，与健康老年人相比差异无统计学意义。（3）dCMAP波幅的降低与老年COPD患者肺功能各指标的减退相关。结论老年COPD患者肺功能的下降与dCMAP降低相关。

The relationship between the lung function changes and compound action potentials of diaphragmatic muscle in elderly patients with chronic obstructive pulmonary disease

Objective To study the relationship of lung function and the diaphragmatic nerve electrophysiological changes in elderly patients with chronic obstructive pulmonary disease(COPD).Methods The phrenic nerve motor conduction(PNC),diaphragmatic motor evoked potentials(dMEP)and diaphragmatic compound muscle action potentials(dCMAP)were detected in 50 COPD patients and 50 healthy controls aged 60 years and over,respectively. Results (1)The lung function of elderly COPD patients were significantly less than that of control group(P<0.05).(2)The elderly COPD group had the same incubation period of PNC in average as that of control group(P>0.05),the lower amplitude of dCMAP than the control(P<0.01),and the normal dMEP as that of the control.(3)The decreas of dCMAP amplitude was significantly correlated with the decrease of the lung function in the elderly COPD patients. Conclusions The changes in lung function of elderly COPD patients were correlated with the changes of dCMAP.