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经皮穿刺椎体成形术治疗90岁以上老人骨质疏松性椎体压缩性骨折
引用本文:章波,杨波,尹飚,唐龙,丁强,秦础强.经皮穿刺椎体成形术治疗90岁以上老人骨质疏松性椎体压缩性骨折[J].中国微创外科杂志,2014(5):445-449.
作者姓名:章波  杨波  尹飚  唐龙  丁强  秦础强
作者单位:广州医科大学附属第三医院骨科,广州510150
基金项目:2008年广东省科技计划项目(社会发展领域重点项目)(2008 A030201015);2011年广州市科技计划项目(应用基础研究计划,引导项目)(2011J4100052)
摘    要:目的 探讨经皮穿刺椎体成形术(percutaneous vertebroplasty,PVP)治疗90岁以上老人骨质疏松性椎体压缩性骨折(osteoporotic vertebral compression fracture,OVCF)的临床疗效。方法 2006年7月~2012年1月,对连续住院的90岁以上老人胸腰椎OVCF 65例行PVP治疗,共计71个椎体,详细记录术前及术后疼痛视觉模拟评分(visual analogue scale,VAS)、止痛药使用评分、活动能力评分、新发骨折情况等。结果 53例获得完整随访,12例因并发心脑血管疾病、肺部感染等内科疾病死亡或失访。术后2小时、5天、1个月、半年及1年的疼痛VAS分别为中位数3.00(1~5)、2.00(0~4)、1.00(O~3)、1.00(0~3)及1.00(0~3),与术前VAS评分8.00(5~10)]比较,差异均有显著性(P〈0.05)。止痛药使用评分术后2小时1.00(0~2)]较术前1.00(0~4)]显著改善(P〈0.05),末次随访时均为0,与术后比较差异显著(P〈0.05)。活动能力评分术后5天2.00(1~3)]较术前4.00(2~4)]明显改善(P〈0.05),末次随访时为2.00(1~3)],活动能力进一步改善。截至末次随访时,lO例新发OVCF,新发骨折率为18.9%(10/53),其中邻近节段骨折7例,发生率13.2%(7/53)。结论 对于90岁以上老人的OVCF,PVP能显著缓解疼痛,明显改善活动能力,减少对止痛药物依赖,是有效可靠的治疗手段。

关 键 词:骨质疏松  90岁以上老人  椎体压缩性骨折  椎体成形术

A Clinical Analysis of Percutaneous Vertebroplasty for Osteoporotic Vertebral Compression Fracture in the Nonagenarian
Institution:Zhang Bo, Yang Bo, Yin Biao, et al.( Department of Orthopaedics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China)
Abstract:Objective To evaluate the curative effect of percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fractures (OVCF) in the nonagenarian. Methods Sixty-five nonagenarian patients with OVCF (71 vertebrae) underwent PVP from July 2006 to January 2012. Subsequent visual analogue scale (VAS) rating, analgesic utilization, mobility and new fractures were recorded before and after the surgery. Results A total of 53 cases were followed up completely and 12 cases were lost due to complicated cardiovascular and cerebrovascular diseases, pulmonary infection or other medlca] diseases. The median VAS score was 8.00 (5-10) preoperative stage and 3.00 (1 -5) at 2 hours after the surgery, and 2.00 (0-4), 1.00 (0-3), 1.00 (0 -3) and 1.00 (0 -3 ) 5 days, 1 month, 6 months and 1 year after the surgery respectively. Compared with the preoperative score, VAS score significantly decreased after the surgery ( P 〈 0.05 ). Analgesic administration score changed from 1. O0 (0 - 4) before PVP to 1. 00 (0 -2) 2 hours after PVP with significant difference (P 〈 0.05) , and became 0. 00 (0 - 0) during the follow-up period, significantly lower than that right after PVP(P 〈0.05). Patients' mobility score decreased from 4.00 (2 -g) ( before PVP) to 2. 00 ( 1 - 3) (5 days after PVP) with significant difference (P 〈 0. 05 ). Ten recurrence fractures were observed ( 18.9% , 10/53 ) after PVP, including 7 patients involving adjacent segment ( 13.2% ,7/53). Conclusions PVP can relieve pain, improve mobility and reduce the dependence on analgesic. PVP for OVCF in the nonagenarian is safe and effective.
Keywords:Osteoporosis  Nonagenarian  Vertebral compression fractures  Vertebroplasty
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